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Protein Ontology report - mitogen-activated protein kinase 1
PR:000000103 -
http://purl.obolibrary.org/obo/PR_000000103
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000103
PRO name
mitogen-activated protein kinase 1
Synonyms
PRO-Short-label
:
EXACT:
MAPK1
Gene-based
:
RELATED:
ERK2 | Mapk | PRKM1 | PRKM2
Other
:
EXACT:
ERK-2 | ERT1 | extracellular signal-regulated kinase 2 | MAP kinase 1 | MAP kinase 2 | MAP kinase isoform p42 | MAPK 1 | MAPK 2 | mitogen-activated protein kinase 2 | p42-MAPK
Definition
"A mitogen-activated protein kinase that is a translation product of the human MAPK1 gene or a 1:1 ortholog thereof." [PRO:CNA]
PRO Category
gene
Parent
PR:000000019
mitogen-activated protein kinase
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
5
Sequence
1
Organism-Sequence
5
Modification
6
Organism-Modification
19
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:1495
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000103
mitogen-activated protein kinase 1
MAPK1
"A mitogen-activated protein kinase that is a translation product of the human MAPK1 gene or a 1:1 ortholog thereof." [PRO:CNA]
organism-gene
PR:P28482
mitogen-activated protein kinase 1 (human)
hMAPK1
"A mitogen-activated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28482]
organism-sequence
PR:P28482-1
mitogen-activated protein kinase 1 isoform 1 (human)
hMAPK1/iso:1
"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000026341
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
hMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]
Yes
organism-sequence
PR:P28482-2
mitogen-activated protein kinase 1 isoform h2 (human)
hMAPK1/iso:h2
"A mitogen-activated protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-2." [PRO:DNx, UniProtKB:P28482]
organism-modification
PR:000045734
mitogen-activated protein kinase 1 phosphorylated 1 (human)
hMAPK1/Phos:1
"A mitogen-activated protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Ser-29, MOD:00046." [iPTMnet:P28482, PMID:19447520]
organism-modification
PR:000048313
mitogen-activated protein kinase 1, initiator methionine removed form (human)
hMAPK1/InitMet-
"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:P28482, 2-360." [PRO:DNx, Reactome:R-HSA-199960, Reactome:R-HSA-59282]
organism-modification
PR:000048314
mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)
hMAPK1/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 185, and phosphotyrosine at position 187 of the amino acid sequence represented by UniProtKB:P28482. UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-109853, Reactome:R-HSA-112354]
organism-modification
PR:000060366
mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321V/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652791]
organism-modification
PR:000060482
mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322K/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-9652175]
organism-modification
PR:000061403
mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58G/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Gly residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:29947|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652802]
organism-modification
PR:000061840
mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E81K/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-81 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Glu-81, CHEBI:29967|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652799]
organism-modification
PR:000062009
mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322V/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652797]
organism-modification
PR:000062395
mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human)
hMAPK1/InitMet-/Phos:2
"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-185 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635773]
organism-modification
PR:000062794
mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321N/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has an Asn residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9652785]
organism-modification
PR:000062965
mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58L/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652806]
organism-modification
PR:000063285
mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:S142L/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Ser-142 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Ser-142, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652808]
organism-modification
PR:000063321
mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322A/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has an Ala residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-9652794]
organism-modification
PR:000083225
mitogen-activated protein kinase 1 cysteinylated 1 (human)
hMAPK1/Cyst:1
"A mitogen-activated protein kinase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-127 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-127, MOD:00765." [IEDB_epitope:1573500, PRO:DNx]
organism-modification
PR:000083581
mitogen-activated protein kinase 1 methylated 1 (human)
hMAPK1/Me:1
"A mitogen-activated protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-166 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-166, MOD:00660." [IEDB_epitope:1024100, PRO:DNx]
organism-modification
PR:000084106
mitogen-activated protein kinase 1 methylated 2 (human)
hMAPK1/Me:2
"A mitogen-activated protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-127 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-127, MOD:00660." [IEDB_epitope:1018447, PRO:DNx]
organism-gene
PR:P39745
mitogen-activated protein kinase mpk-1 (worm)
MAPK1 (worm)
"A mitogen-activated protein kinase 1 that is encoded in the genome of worm." [OMA:P39745, PRO:DNx]
organism-sequence
PR:P39745-1
mitogen-activated protein kinase mpk-1 isoform b (worm)
MAPK1/iso:b (worm)
"A mitogen-activated protein kinase mpk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39745-1." [PRO:DNx, UniProtKB:P39745]
organism-sequence
PR:P39745-2
mitogen-activated protein kinase mpk-1 isoform a (worm)
MAPK1/iso:a (worm)
"A mitogen-activated protein kinase mpk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39745-2." [PRO:DNx, UniProtKB:P39745]
organism-gene
PR:P42525
extracellular signal-regulated kinase 1 (Dictyostelium discoideum)
Dicty-MAPK1
"A mitogen-activated protein kinase 1 that is encoded in the genome of Dictyostelium discoideum." [PRO:CNA]
organism-gene
PR:P63085
mitogen-activated protein kinase 1 (mouse)
mMAPK1
"A mitogen-activated protein kinase 1 that is encoded in the genome of mouse." [OMA:P63085, PRO:DNx]
organism-sequence
PR:P63085-1
mitogen-activated protein kinase 1 isoform 1 (mouse)
mMAPK1/iso:1
"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036464
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)
mMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA]
Yes
organism-gene
PR:P63086
mitogen-activated protein kinase 1 (rat)
rMAPK1
"A mitogen-activated protein kinase 1 that is encoded in the genome of rat." [OMA:P63086, PRO:DNx]
organism-modification
PR:000036466
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat)
rMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in rat. UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:9604935, PRO:CNA]
Yes
sequence
PR:000000289
mitogen-activated protein kinase 1 isoform 1
MAPK1/iso:1
"A mitogen-activated protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
organism-sequence
PR:P28482-1
mitogen-activated protein kinase 1 isoform 1 (human)
hMAPK1/iso:1
"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000026341
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
hMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]
Yes
organism-sequence
PR:P63085-1
mitogen-activated protein kinase 1 isoform 1 (mouse)
mMAPK1/iso:1
"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036464
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)
mMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA]
Yes
modification
PR:000000454
mitogen-activated protein kinase 1 isoform 1 phosphorylated form
MAPK1/iso:1/PhosRes+
"A mitogen-activated protein kinase 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
modification
PR:000000556
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1
MAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated form that is phosphorylated at both Thr and Tyr of the TxY motif within the protein kinase domain. Example: UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PMID:17192257, PMID:1849075, PRO:CNA]
organism-modification
PR:000026341
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
hMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]
Yes
organism-modification
PR:000036464
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)
mMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA]
Yes
organism-modification
PR:000036466
mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat)
rMAPK1/iso:1/Phos:1
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in rat. UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:9604935, PRO:CNA]
Yes
modification
PR:000025465
mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form
MAPK1/iso:1/InitMet-
"A mitogen-activated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]
modification
PR:000000453
mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form
MAPK1/iso:1/InitMet-/AcRes+
"A mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form that includes at least one acetylated residue." [PMID:12665801, PRO:CNA]
modification
PR:000018278
mitogen-activated protein kinase 1, initiator methionine removed form
MAPK1/InitMet-
"A mitogen-activated protein kinase 1 that has had the initiator methionine removed." [PRO:DNx]
modification
PR:000025465
mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form
MAPK1/iso:1/InitMet-
"A mitogen-activated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]
modification
PR:000000453
mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form
MAPK1/iso:1/InitMet-/AcRes+
"A mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form that includes at least one acetylated residue." [PMID:12665801, PRO:CNA]
organism-modification
PR:000048313
mitogen-activated protein kinase 1, initiator methionine removed form (human)
hMAPK1/InitMet-
"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:P28482, 2-360." [PRO:DNx, Reactome:R-HSA-199960, Reactome:R-HSA-59282]
organism-modification
PR:000048314
mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)
hMAPK1/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 185, and phosphotyrosine at position 187 of the amino acid sequence represented by UniProtKB:P28482. UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-109853, Reactome:R-HSA-112354]
organism-modification
PR:000060366
mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321V/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652791]
organism-modification
PR:000060482
mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322K/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-9652175]
organism-modification
PR:000061403
mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58G/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Gly residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:29947|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652802]
organism-modification
PR:000061840
mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E81K/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-81 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Glu-81, CHEBI:29967|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652799]
organism-modification
PR:000062009
mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322V/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652797]
organism-modification
PR:000062395
mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human)
hMAPK1/InitMet-/Phos:2
"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-185 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635773]
organism-modification
PR:000062794
mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:D321N/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has an Asn residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9652785]
organism-modification
PR:000062965
mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:P58L/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652806]
organism-modification
PR:000063285
mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:S142L/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Ser-142 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Ser-142, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652808]
organism-modification
PR:000063321
mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human)
hMAPK1/var:E322A/InitMet-/Phos:1
"A mitogen-activated protein kinase 1 (human) that has an Ala residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-9652794]
modification
PR:000025458
mitogen-activated protein kinase 1 proteolytic cleavage product
MAPK1/ClvPrd
"A mitogen-activated protein kinase 1 that has been processed by proteolytic cleavage." [PRO:DNx]
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026341
hMAPK1/iso:1/Phos:1
UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:10958679
GO:0006935
chemotaxis
PMID:10706854
GO:0007165
signal transduction
PMID:1540184
enables
GO:0004672
protein kinase activity
PMID:10706854
GO:0004707
MAP kinase activity
PMID:10706854
GO:0005515
protein binding
PMID:16291755
PR:000036464
mMAPK1/iso:1/Phos:1
UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048
acts_upstream_of_or_within
GO:0000165
MAPK cascade
PMID:8626447
GO:0006468
protein phosphorylation
PMID:15284227
GO:0007165
signal transduction
PMID:11684667
enables
GO:0004672
protein kinase activity
PMID:14744933
GO:0004707
MAP kinase activity
PMID:11684667
;
PMID:12223545
;
PMID:15314156
;
PMID:8626447
located_in
GO:0005634
nucleus
PMID:11726647
;
PMID:12925581
;
PMID:16251435
PR:000036466
rMAPK1/iso:1/Phos:1
UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048
enables
GO:0042803
protein homodimerization activity
PMID:9604935
PR:P28482-1
hMAPK1/iso:1
acts_upstream_of_or_within
GO:0006935
chemotaxis
PMID:10706854
GO:0006950
response to stress
PMID:10958679
GO:0007268
chemical synaptic transmission
PMID:10706854
enables
NOT
GO:0004707
MAP kinase activity
PMID:10706854
PR:P63085-1
mMAPK1/iso:1
located_in
GO:0005737
cytoplasm
PMID:11726647
;
PMID:12223545
