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Protein Ontology report - lefty protein
PR:000000102 - http://purl.obolibrary.org/obo/PR_000000102
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000102   
  PRO namelefty protein 
  Definition"A TGF-beta-like cystine-knot cytokine that is an antagonist of nodal signaling. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification6                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037402
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000102 lefty protein
LTBP1
Yes
gene


PR:000000287 lefty 1
LEFTY1

organism-gene


PR:O75610 left-right determination factor 1 (human)
hLEFTY1

organism-sequence


PR:O75610-1 left-right determination factor 1 isoform 1 (human)
hLEFTY1/iso:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
organism-modification


PR:000077301 left-right determination factor 1 phosphorylated 1 (human)
hLEFTY1/Phos:1

sequence


PR:000000450 lefty 1 isoform 1
LEFTY1/iso:1

organism-sequence


PR:O75610-1 left-right determination factor 1 isoform 1 (human)
hLEFTY1/iso:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
organism-sequence


PR:Q64280-1 left-right determination factor 1 isoform 1 (mouse)
mLEFTY1/iso:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse)
mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000643 lefty 1 isoform 1 cleaved 1
LEFTY1/iso:1/Clv:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse)
mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000644 lefty 1 isoform 1 cleaved 2
LEFTY1/iso:1/Clv:2

organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
modification


PR:000025431 lefty 1 proteolytic cleavage product
LEFTY1/ClvPrd

modification


PR:000000643 lefty 1 isoform 1 cleaved 1
LEFTY1/iso:1/Clv:1

organism-modification


PR:000036546 lefty 1 isoform 1 cleaved 1 (human)
hLEFTY1/iso:1/Clv:1
Yes
organism-modification


PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse)
mLEFTY1/iso:1/Clv:1
Yes
modification


PR:000000644 lefty 1 isoform 1 cleaved 2
LEFTY1/iso:1/Clv:2

organism-modification


PR:000036548 lefty 1 isoform 1 cleaved 2 (human)
hLEFTY1/iso:1/Clv:2
Yes
gene


PR:000000288 lefty 2
LEFTY2

organism-gene


PR:O00292 left-right determination factor 2 (human)
hLEFTY2

organism-sequence


PR:000000452 lefty 2 sequence variant S342N (human)
hLEFTY2/var:S342N
Yes
organism-sequence


PR:O00292-1 left-right determination factor 2 isoform 1 (human)
hLEFTY2/iso:1
Yes
organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human)
hLEFTY2/iso:1/Clv:1
Yes
organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human)
hLEFTY2/iso:1/Clv:2
Yes
organism-sequence


PR:O00292-2 left-right determination factor 2 isoform h2 (human)
hLEFTY2/iso:h2

organism-modification


PR:000048185 left-right determination factor 2, signal peptide removed form (human)
hLEFTY2/SigPep-

organism-modification


PR:000083292 left-right determination factor 2 phosphorylated 1 (human)
hLEFTY2/Phos:1

sequence


PR:000000451 lefty 2 isoform 1
LEFTY2/iso:1

organism-sequence


PR:O00292-1 left-right determination factor 2 isoform 1 (human)
hLEFTY2/iso:1
Yes
organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human)
hLEFTY2/iso:1/Clv:1
Yes
organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human)
hLEFTY2/iso:1/Clv:2
Yes
organism-sequence


PR:P57785-1 left-right determination factor 2 isoform 1 (mouse)
mLEFTY2/iso:1

modification


PR:000000645 lefty 2 isoform 1 cleaved 1
LEFTY2/iso:1/Clv:1

organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human)
hLEFTY2/iso:1/Clv:1
Yes
modification


PR:000000646 lefty 2 isoform 1 cleaved 2
LEFTY2/iso:1/Clv:2

organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human)
hLEFTY2/iso:1/Clv:2
Yes
modification


PR:000025432 lefty 2 proteolytic cleavage product
LEFTY2/ClvPrd

modification


PR:000000645 lefty 2 isoform 1 cleaved 1
LEFTY2/iso:1/Clv:1

organism-modification


PR:000036549 lefty 2 isoform 1 cleaved 1 (human)
hLEFTY2/iso:1/Clv:1
Yes
modification


PR:000000646 lefty 2 isoform 1 cleaved 2
LEFTY2/iso:1/Clv:2

organism-modification


PR:000036550 lefty 2 isoform 1 cleaved 2 (human)
hLEFTY2/iso:1/Clv:2
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007275 multicellular organism developmentPR:000000102 LTBP1 PIRSF:PIRSF037402
PR:000036549 hLEFTY2/iso:1/Clv:1 PMID:10053005
PR:O00292-1 hLEFTY2/iso:1 PMID:10053005
GO:0007309 oocyte axis specificationPR:000036549 hLEFTY2/iso:1/Clv:1 PMID:10053005
PR:O00292-1 hLEFTY2/iso:1 PMID:10053005
GO:0008285 negative regulation of cell population proliferationPR:000036547 mLEFTY1/iso:1/Clv:1 PMID:15004567
PR:Q64280-1 mLEFTY1/iso:1 PMID:15004567
GO:0009948 anterior/posterior axis specificationPR:000036547 mLEFTY1/iso:1/Clv:1 PMID:15004567
PR:Q64280-1 mLEFTY1/iso:1 PMID:15004567
GO:0043406 positive regulation of MAP kinase activityPR:000036548 hLEFTY1/iso:1/Clv:2 PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2 PMID:11278322

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050545 visceral heterotaxyPR:000000452 hLEFTY2/var:S342N PMID:10053005

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036546 hLEFTY1/iso:1/Clv:1 PMID:11278322
PR:000036547 mLEFTY1/iso:1/Clv:1 PMID:18039650
PR:000036548 hLEFTY1/iso:1/Clv:2 PMID:11278322
PR:000036549 hLEFTY2/iso:1/Clv:1 PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2 PMID:11278322