|
|
 |
|
| | |
| | | | | | | | |
family
|
|
PR:000000099 |
inhibitory smad protein
|
FST/iso:2
|
"A smad protein that is an antagonist of the transforming growth factor beta (TGF-beta) superfamily signaling pathways. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation that is present in the receptor-regulated smads." [PMID:11532220]
|
Yes |
|
|
|
|
|
| | | | |
| | | | | | |
gene
|
|
PR:000000373 |
smad6
|
SMAD6
|
"An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6." [PMID:17493940]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:O35182 |
mothers against decapentaplegic homolog 6 (mouse)
|
mSMAD6
|
"A smad6 that is encoded in the genome of mouse." [OMA:O35182, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O35182-1 |
mothers against decapentaplegic homolog 6 isoform 1 (mouse)
|
mSMAD6/iso:1
|
"A smad6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036564 |
smad6 isoform 1 dimethylated 1 (mouse)
|
mSMAD6/iso:1/Me2:1
|
"A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:O43541 |
mothers against decapentaplegic homolog 6 (human)
|
hSMAD6
|
"A smad6 that is encoded in the genome of human." []
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O43541-1 |
mothers against decapentaplegic homolog 6 isoform A (human)
|
hSMAD6/iso:A
|
"A smad6 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O43541-2 |
mothers against decapentaplegic homolog 6 isoform B (human)
|
hSMAD6/iso:B
|
"A smad6 isoform 2 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O43541-4 |
mothers against decapentaplegic homolog 6 isoform D (human)
|
hSMAD6/iso:D
|
"A mothers against decapentaplegic homolog 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-4." [PRO:DNx, UniProtKB:O43541]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:Q9W734 |
mothers against decapentaplegic homolog 6 (chicken)
|
chick-SMAD6
|
"A smad6 that is encoded in the genome of chicken." [OMA:Q9W734, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
sequence
|
|
PR:000000479 |
smad6 isoform 1
|
SMAD6/iso:1
|
"A smad6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O35182-1 |
mothers against decapentaplegic homolog 6 isoform 1 (mouse)
|
mSMAD6/iso:1
|
"A smad6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036564 |
smad6 isoform 1 dimethylated 1 (mouse)
|
mSMAD6/iso:1/Me2:1
|
"A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O43541-1 |
mothers against decapentaplegic homolog 6 isoform A (human)
|
hSMAD6/iso:A
|
"A smad6 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | |
modification
|
|
PR:000000581 |
smad6 isoform 1 dimethylated form
|
SMAD6/iso:1/Me2Res+
|
"A smad6 isoform 1 that includes at least one dimethylated residue." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
modification
|
|
PR:000000662 |
smad6 isoform 1 dimethylated 1
|
SMAD6/iso:1/Me2:1
|
"A smad6 isoform 1 dimethylated form that has been dimethylated at Arg residues within the MH1 domain by PRMT1. Example: UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358]
|
|
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036564 |
smad6 isoform 1 dimethylated 1 (mouse)
|
mSMAD6/iso:1/Me2:1
|
"A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | |
| | | | |
sequence
|
|
PR:000000480 |
smad6 isoform 2
|
SMAD6/iso:2
|
"A smad6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-2 or a 1:1 ortholog thereof." [PMID:11284962, PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O43541-2 |
mothers against decapentaplegic homolog 6 isoform B (human)
|
hSMAD6/iso:B
|
"A smad6 isoform 2 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | |
| | | | | | |
gene
|
|
PR:000000374 |
smad7
|
SMAD7
|
"An inhibitory smad protein that is a translation product of the human SMAD7 gene or a 1:1 ortholog thereof. Smad7 is a negative regulator of TGF-beta signaling." [PMID:17438144]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:O15105 |
mothers against decapentaplegic homolog 7 (human)
|
hSMAD7
|
"A smad7 that is encoded in the genome of human." []
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O15105-1 |
mothers against decapentaplegic homolog 7 isoform 1 (human)
|
hSMAD7/iso:1
|
"A smad7 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036565 |
smad7 isoform 1 acetylated 1 (human)
|
hSMAD7/iso:1/Ac:1
|
"A smad7 isoform 1 acetylated 1 in human. UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064." [PMID:12408818, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036566 |
smad7 isoform 1 phosphorylated 1 (human)
|
hSMAD7/iso:1/Phos:1
|
"A smad7 isoform 1 phosphorylated 1 in human. UniProtKB:O15105-1, Ser-249, MOD:00046." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O15105-2 |
mothers against decapentaplegic homolog 7 isoform h2 (human)
|
hSMAD7/iso:h2
|
"A mothers against decapentaplegic homolog 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15105-2." [PRO:DNx, UniProtKB:O15105]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O15105-3 |
mothers against decapentaplegic homolog 7 isoform 3 (human)
|
hSMAD7/iso:3
|
"A smad7 isoform 3 that is encoded in the genome of human." [PRO:DNx]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:O35253 |
mothers against decapentaplegic homolog 7 (mouse)
|
mSMAD7
|
"A smad7 that is encoded in the genome of mouse." [OMA:O35253, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O35253-1 |
mothers against decapentaplegic homolog 7 isoform A (mouse)
|
mSMAD7/iso:A
|
"A smad7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036932 |
smad7 isoform 1 phosphorylated 1 (mouse)
|
mSMAD7/iso:1/Phos:1
|
"A smad7 isoform 1 phosphorylated 1 in mouse. UniProtKB:O35253-1, Ser-249, MOD:00046." [PMID:11278814, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000049801 |
mothers against decapentaplegic homolog 7 isoform A monomethylated 1 (mouse)
|
mSMAD7/iso:A/Me1:1
|
"A mothers against decapentaplegic homolog 7 isoform A (mouse) that has been monomethylated at the position equivalent to Lys-70. UniProtKB:O35253-1, Lys-70, MOD:00085." [PMID:27292644, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000049802 |
mothers against decapentaplegic homolog 7 isoform A unmethylated 1 (mouse)
|
mSMAD7/iso:A/UnMe:1
|
"A mothers against decapentaplegic homolog 7 isoform A (mouse) that lacks a monomethylated Lys at position 70. UniProtKB:O35253-1, Lys-70, PR:000026291." [PMID:27292644, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O35253-2 |
mothers against decapentaplegic homolog 7 isoform B (mouse)
|
mSMAD7/iso:B
|
"A smad7 isoform 3 that is encoded in the genome of mouse." [PRO:DNx]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:O88406 |
mothers against decapentaplegic homolog 7 (rat)
|
rSMAD7
|
"A smad7 that is encoded in the genome of rat." [OMA:O88406, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
sequence
|
|
PR:000000481 |
smad7 isoform 1
|
SMAD7/iso:1
|
"A smad7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35253-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O15105-1 |
mothers against decapentaplegic homolog 7 isoform 1 (human)
|
hSMAD7/iso:1
|
"A smad7 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036565 |
smad7 isoform 1 acetylated 1 (human)
|
hSMAD7/iso:1/Ac:1
|
"A smad7 isoform 1 acetylated 1 in human. UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064." [PMID:12408818, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036566 |
smad7 isoform 1 phosphorylated 1 (human)
|
hSMAD7/iso:1/Phos:1
|
"A smad7 isoform 1 phosphorylated 1 in human. UniProtKB:O15105-1, Ser-249, MOD:00046." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O35253-1 |
mothers against decapentaplegic homolog 7 isoform A (mouse)
|
mSMAD7/iso:A
|
"A smad7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036932 |
smad7 isoform 1 phosphorylated 1 (mouse)
|
mSMAD7/iso:1/Phos:1
|
"A smad7 isoform 1 phosphorylated 1 in mouse. UniProtKB:O35253-1, Ser-249, MOD:00046." [PMID:11278814, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000049801 |
mothers against decapentaplegic homolog 7 isoform A monomethylated 1 (mouse)
|
mSMAD7/iso:A/Me1:1
|
"A mothers against decapentaplegic homolog 7 isoform A (mouse) that has been monomethylated at the position equivalent to Lys-70. UniProtKB:O35253-1, Lys-70, MOD:00085." [PMID:27292644, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000049802 |
mothers against decapentaplegic homolog 7 isoform A unmethylated 1 (mouse)
|
mSMAD7/iso:A/UnMe:1
|
"A mothers against decapentaplegic homolog 7 isoform A (mouse) that lacks a monomethylated Lys at position 70. UniProtKB:O35253-1, Lys-70, PR:000026291." [PMID:27292644, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
modification
|
|
PR:000000582 |
smad7 isoform 1 acetylated form
|
SMAD7/iso:1/AcRes+
|
"A smad7 isoform 1 that includes at least one acetylated residue." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
modification
|
|
PR:000000663 |
smad7 isoform 1 acetylated 1
|
SMAD7/iso:1/Ac:1
|
"A smad7 isoform 1 acetylated form that has been acetylated at Lys residues within the MH1 domain by Histone acetyltransferase p300. Example: UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064." [PMID:12408818]
|
|
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036565 |
smad7 isoform 1 acetylated 1 (human)
|
hSMAD7/iso:1/Ac:1
|
"A smad7 isoform 1 acetylated 1 in human. UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064." [PMID:12408818, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | |
modification
|
|
PR:000000583 |
smad7 isoform 1 phosphorylated form
|
SMAD7/iso:1/PhosRes+
|
"A smad7 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
modification
|
|
PR:000000664 |
smad7 isoform 1 phosphorylated 1
|
SMAD7/iso:1/Phos:1
|
"A smad7 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue within the DSQL sequence region in the MH2 domain. Example: UniProtKB:O15105-1, Ser-249, MOD:00046." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036566 |
smad7 isoform 1 phosphorylated 1 (human)
|
hSMAD7/iso:1/Phos:1
|
"A smad7 isoform 1 phosphorylated 1 in human. UniProtKB:O15105-1, Ser-249, MOD:00046." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | | | |
organism-modification
|
|
PR:000036932 |
smad7 isoform 1 phosphorylated 1 (mouse)
|
mSMAD7/iso:1/Phos:1
|
"A smad7 isoform 1 phosphorylated 1 in mouse. UniProtKB:O35253-1, Ser-249, MOD:00046." [PMID:11278814, PRO:CNA]
|
Yes |
|
|
|
|
|
| | | | | | | | |
| | |
modification
|
|
PR:000000584 |
smad7 isoform 1 ubiquitinated form
|
SMAD7/iso:1/UbiqLys+
|
"A smad7 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | | | |
|
modification
|
|
PR:000000665 |
smad7 isoform 1 ubiquitinated 1
|
SMAD7/iso:1/Ubiq:1
|
"A smad7 isoform 1 ubiquitinated form that has been ubiquitinated at Lys residues within the MH1 domain by Smurf proteins. This targets smad7 for proteosomal degradation." [PMID:12408818]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
sequence
|
|
PR:000038037 |
smad7 isoform 3
|
SMAD7/iso:3
|
"A smad7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15105-3 or a 1:1 ortholog thereof." [PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O15105-3 |
mothers against decapentaplegic homolog 7 isoform 3 (human)
|
hSMAD7/iso:3
|
"A smad7 isoform 3 that is encoded in the genome of human." [PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O35253-2 |
mothers against decapentaplegic homolog 7 isoform B (mouse)
|
mSMAD7/iso:B
|
"A smad7 isoform 3 that is encoded in the genome of mouse." [PRO:DNx]
|
|
|
|
|
