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Protein Ontology report - CREB-binding protein

PR:000000090 - http://purl.obolibrary.org/obo/PR_000000090

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000090

PRO name

CREB-binding protein

Synonyms

PRO-Short-label:	EXACT:	CREBBP
Gene-based:	RELATED:	CBP
Other:	EXACT:	protein lactyltransferas CREBBP \| protein-lysine acetyltransferase CREBBP

Definition

"A transcription adapter with TAZ, KIX and bromo-domains that is a translation product of the human CREBBP gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000031 transcription adapter with TAZ, KIX and bromo-domains

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	3
Sequence	1	Organism-Sequence	4
Modification	4	Organism-Modification	5

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	IUPHARobj:2734

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Protein Forms

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Category

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000090

CREB-binding protein

CREBBP

"A transcription adapter with TAZ, KIX and bromo-domains that is a translation product of the human CREBBP gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene

PR:P45481

histone lysine acetyltransferase CREBBP (mouse)

mCREBBP

"A CREB-binding protein that is encoded in the genome of mouse." [OMA:P45481, PMID:8413673]

organism-sequence

PR:P45481-1

CREB-binding protein isoform 1 (mouse)

mCREBBP/iso:1

"A CREB-binding protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification

PR:000036453

CREB-binding protein isoform 1 methylated 1 (mouse)

mCREBBP/iso:1/Me:1

"A CREB-binding protein isoform 1 methylated 1 in mouse. UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890, PRO:CNA]

Yes

organism-modification

PR:000077765

histone lysine acetyltransferase CREBBP cysteinylated 1 (mouse)

mCREBBP/Cyst:1

"A histone lysine acetyltransferase CREBBP (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-1179 of the amino acid sequence represented by UniProtKB:P45481. UniProtKB:P45481, Cys-1179, MOD:00765." [IEDB_epitope:2106235, PRO:DNx]

organism-gene

PR:Q6JHU9

histone lysine acetyltransferase CREBBP (rat)

rCREBBP

"A CREB-binding protein that is encoded in the genome of rat." [OMA:Q6JHU9, PRO:DNx]

organism-gene

PR:Q92793

CREB-binding protein (human)

hCREBBP

"A CREB-binding protein that is encoded in the genome of human." [PMID:11331617]

organism-sequence

PR:000000266

CREB-binding protein sequence variant R1378P (human)

hCREBBP/var:R1378P

"A CREB-binding protein (human) that has a Pro residue at the position equivalent to Arg-1378 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342." [PMID:11331617, PRO:CNA, PRO:DAN]

Yes

organism-sequence

PR:Q92793-1

CREB-binding protein isoform 1 (human)

hCREBBP/iso:1

"A CREB-binding protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence

PR:Q92793-2

CREB-binding protein isoform h2 (human)

hCREBBP/iso:h2

"A CREB-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92793-2." [PRO:DNx, UniProtKB:Q92793]

organism-modification

PR:000064816

CREB-binding protein sumoylated 1 (human)

hCREBBP/Sumo:1

"A CREB-binding protein (human) that has been sumoylated on the residues at the positions equivalent to Lys-998, Lys-1033, and Lys-1056 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Lys-998/Lys-1033/Lys-1056, MOD:01149." [PRO:DNx, Reactome:R-HSA-3927877]

organism-modification

PR:000067783

CREB-binding protein phosphorylated 1 (human)

hCREBBP/Phos:1

"A CREB-binding protein (human) that has been phosphorylated on the residue at the position equivalent to Ser-868 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Ser-868, MOD:00046." [IEDB_epitope:1372378, PRO:DNx]

organism-modification

PR:000080126

CREB-binding protein phosphorylated 2 (human)

hCREBBP/Phos:2

"A CREB-binding protein (human) that has been phosphorylated on the residue at the position equivalent to Tyr-1539 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Tyr-1539, MOD:00048." [IEDB_epitope:2149301, PRO:DNx]

sequence

PR:000000265

CREB-binding protein isoform 1

CREBBP/iso:1

"A CREB-binding protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92793-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence

PR:P45481-1

CREB-binding protein isoform 1 (mouse)

mCREBBP/iso:1

"A CREB-binding protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification

PR:000036453

CREB-binding protein isoform 1 methylated 1 (mouse)

mCREBBP/iso:1/Me:1

"A CREB-binding protein isoform 1 methylated 1 in mouse. UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890, PRO:CNA]

Yes

organism-sequence

PR:Q92793-1

CREB-binding protein isoform 1 (human)

hCREBBP/iso:1

"A CREB-binding protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

modification

PR:000000426

CREB-binding protein isoform 1 methylated form

CREBBP/iso:1/MeRes+

"A CREB-binding protein isoform 1 that includes at least one methylated residue." [PRO:CNA]

modification

PR:000000541

CREB-binding protein isoform 1 methylated 1

CREBBP/iso:1/Me:1

"A CREB-binding protein isoform 1 methylated form that has been methylated at arginine residues within the KIX domain. Example: UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890]

organism-modification

PR:000036453

CREB-binding protein isoform 1 methylated 1 (mouse)

mCREBBP/iso:1/Me:1

"A CREB-binding protein isoform 1 methylated 1 in mouse. UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890, PRO:CNA]

Yes

modification

PR:000026573

CREB-binding protein isoform 1, initiator methionine removed form

CREBBP/iso:1/InitMet-

"A CREB-binding protein isoform 1 that has had the initiator methionine removed." [PRO:DNx]

modification

PR:000018275

CREB-binding protein, initiator methionine removed form

CREBBP/InitMet-

"A CREB-binding protein that has had the initiator methionine removed." [PRO:DNx]

modification

PR:000026573

CREB-binding protein isoform 1, initiator methionine removed form

CREBBP/iso:1/InitMet-

"A CREB-binding protein isoform 1 that has had the initiator methionine removed." [PRO:DNx]

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Functional Annotation (GO-centric view)

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Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0006355 regulation of DNA-templated transcription	PR:Q92793-1 hCREBBP/iso:1	PMID:12169688; PMID:7913207
GO:0045893 positive regulation of DNA-templated transcription	PR:P45481-1 mCREBBP/iso:1	PMID:15464984
	PR:Q92793-1 hCREBBP/iso:1	PMID:11742995
Disease Associated GO Term	Protein Forms & Complexes	Evidence
DO:1933 Rubinstein-Taybi syndrome	PR:000000266 hCREBBP/var:R1378P	PMID:11331617
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0003713 transcription coactivator activity	PR:Q92793-1 hCREBBP/iso:1	PMID:10733899; PMID:10893273; PMID:12169688; PMID:12586840; PMID:8684459
GO:0004402 histone acetyltransferase activity	PR:P45481-1 mCREBBP/iso:1	PMID:11867645
GO:0004402 histone acetyltransferase activity	PR:Q92793-1 hCREBBP/iso:1	PMID:11742995
NOT GO:0004402 histone acetyltransferase activity	PR:000000266 hCREBBP/var:R1378P	PMID:11331617
GO:0005515 protein binding	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
	PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
PR:Q92793-1 hCREBBP/iso:1	PMID:11799127
GO:0016407 acetyltransferase activity	PR:P45481-1 mCREBBP/iso:1	PMID:12496368
GO:0016407 acetyltransferase activity	PR:Q92793-1 hCREBBP/iso:1	PMID:11742995
Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0000123 histone acetyltransferase complex	PR:Q92793-1 hCREBBP/iso:1	PMID:9742083
NOT GO:0000123 histone acetyltransferase complex	PR:000036453 mCREBBP/iso:1/Me:1	PMID:11701890
GO:0005634 nucleus	PR:000036453 mCREBBP/iso:1/Me:1	PMID:11701890
	PR:P45481-1 mCREBBP/iso:1	PMID:11963968; PMID:12496368
	PR:Q92793-1 hCREBBP/iso:1	PMID:7913207
SO:0001559 polypeptide_loss_of_function_variant	PR:000000266 hCREBBP/var:R1378P	PMID:11331617