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Protein Ontology report - c-myc protein
PR:000000084 - http://purl.obolibrary.org/obo/PR_000000084
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000084   
  PRO namec-myc protein 
  Synonyms
PRO-Short-label: EXACT:MYC
Gene-based: RELATED:BHLHE39
Other: EXACT:bHLHe39 | class E basic helix-loop-helix protein 39 | proto-oncogene c-Myc | transcription factor p64
  Definition"A Myc protein that is a translation product of the human MYC gene or a 1:1 ortholog thereof. The gene has 3 exons, with exon 1 lacking ATG codons." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000020 Myc protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence2                                                  Organism-Sequence 13                                        
         Modification10                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000084 c-myc protein
MYC

organism-gene


PR:P01106 Myc proto-oncogene protein (human)
hMYC

Yes
organism-sequence


PR:P01106-1 c-myc protein isoform 1 (human)
hMYC/iso:1
Yes
organism-modification


PR:000026033 c-myc protein isoform 1 acetylated 1 (human)
hMYC/iso:1/Ac:1
Yes
Yes
organism-modification


PR:000026038 c-myc protein isoform 1 unmodified form (human)
hMYC/iso:1/UnMod

Yes
organism-modification


PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human)
hMYC/iso:1/Phos:4

organism-modification


PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human)
hMYC/iso:1/OGlyco:1
Yes
organism-modification


PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human)
hMYC/iso:1/Phos:2
Yes
organism-modification


PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human)
hMYC/iso:1/Phos:3
Yes
organism-modification


PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human)
hMYC/iso:1/Phos:1
Yes
organism-sequence


PR:P01106-2 c-myc protein isoform 2 (human)
hMYC/iso:2
Yes
organism-sequence


PR:P01106-3 Myc proto-oncogene protein isoform h3 (human)
hMYC/iso:h3

organism-modification


PR:000048491 Myc proto-oncogene protein ubiquitinated form (human)
hMYC/UbiqLys+

organism-modification


PR:000077803 Myc proto-oncogene protein deaminated 1 (human)
hMYC/Deam:1

organism-gene


PR:P01108 Myc proto-oncogene protein (mouse)
mMYC

organism-sequence


PR:B2RSN1 c-myc protein isoform 2 (mouse)
mMYC/iso:2
Yes
organism-sequence


PR:P01108-1 c-myc protein isoform 1 (mouse)
mMYC/iso:1
Yes
organism-modification


PR:000026052 c-myc protein isoform 1 phosphorylated 1 (mouse)
mMYC/iso:1/Phos:1
Yes
organism-modification


PR:000026053 c-myc protein isoform 1 phosphorylated 2 (mouse)
mMYC/iso:1/Phos:2
Yes
organism-sequence


PR:P01108-2 Myc proto-oncogene protein isoform m1 (mouse)
mMYC/iso:m1

organism-sequence


PR:P01108-3 Myc proto-oncogene protein isoform m3 (mouse)
mMYC/iso:m3

organism-gene


PR:P01109 Myc proto-oncogene protein (chicken)
chick-MYC

organism-sequence


PR:P01109-1 Myc proto-oncogene protein isoform 2 (chicken)
chick-MYC/iso:2

organism-sequence


PR:P01109-2 Myc proto-oncogene protein isoform 1 (chicken)
chick-MYC/iso:1

organism-gene


PR:P09416 Myc proto-oncogene protein (rat)
rMYC

organism-sequence


PR:P09416-1 Myc proto-oncogene protein isoform r2 (rat)
rMYC/iso:r2

organism-sequence


PR:P09416-2 Myc proto-oncogene protein isoform r1 (rat)
rMYC/iso:r1

organism-gene


PR:P52160 transcriptional regulator Myc-A (zebrafish)
z-MYC

organism-sequence


PR:P52160-1 transcriptional regulator Myc-A isoform 2 (zebrafish)
z-MYC/iso:2

organism-sequence


PR:P52160-2 transcriptional regulator Myc-A isoform 1 (zebrafish)
z-MYC/iso:1

sequence


PR:000000228 c-myc protein isoform 1
MYC/iso:1

organism-sequence


PR:P01106-1 c-myc protein isoform 1 (human)
hMYC/iso:1
Yes
organism-modification


PR:000026033 c-myc protein isoform 1 acetylated 1 (human)
hMYC/iso:1/Ac:1
Yes
Yes
organism-modification


PR:000026038 c-myc protein isoform 1 unmodified form (human)
hMYC/iso:1/UnMod

Yes
organism-modification


PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human)
hMYC/iso:1/Phos:4

organism-modification


PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human)
hMYC/iso:1/OGlyco:1
Yes
organism-modification


PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human)
hMYC/iso:1/Phos:2
Yes
organism-modification


PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human)
hMYC/iso:1/Phos:3
Yes
organism-modification


PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human)
hMYC/iso:1/Phos:1
Yes
organism-sequence


PR:P01108-1 c-myc protein isoform 1 (mouse)
mMYC/iso:1
Yes
organism-modification


PR:000026052 c-myc protein isoform 1 phosphorylated 1 (mouse)
mMYC/iso:1/Phos:1
Yes
organism-modification


PR:000026053 c-myc protein isoform 1 phosphorylated 2 (mouse)
mMYC/iso:1/Phos:2
Yes
modification


PR:000000420 c-myc protein isoform 1 acetylated form
MYC/iso:1/AcRes+

modification


PR:000000535 c-myc protein isoform 1 acetylated 1
MYC/iso:1/Ac:1

organism-modification


PR:000026033 c-myc protein isoform 1 acetylated 1 (human)
hMYC/iso:1/Ac:1
Yes
Yes
modification


PR:000000421 c-myc protein isoform 1 glycosylated form
MYC/iso:1/GlycoRes+

modification


PR:000000536 c-myc protein isoform 1 O-glycosylated 1
MYC/iso:1/OGlyco:1

organism-modification


PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human)
hMYC/iso:1/OGlyco:1
Yes
modification


PR:000000422 c-myc protein isoform 1 phosphorylated form
MYC/iso:1/PhosRes+

modification


PR:000000537 c-myc protein isoform 1 phosphorylated 1
MYC/iso:1/Phos:1

organism-modification


PR:000026052 c-myc protein isoform 1 phosphorylated 1 (mouse)
mMYC/iso:1/Phos:1
Yes
organism-modification


PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human)
hMYC/iso:1/Phos:1
Yes
modification


PR:000000538 c-myc protein isoform 1 phosphorylated 2
MYC/iso:1/Phos:2

organism-modification


PR:000026053 c-myc protein isoform 1 phosphorylated 2 (mouse)
mMYC/iso:1/Phos:2
Yes
organism-modification


PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human)
hMYC/iso:1/Phos:2
Yes
modification


PR:000000539 c-myc protein isoform 1 phosphorylated 3
MYC/iso:1/Phos:3

organism-modification


PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human)
hMYC/iso:1/Phos:3
Yes
modification


PR:000026040 c-myc protein isoform 1 phosphorylated 4
MYC/iso:1/Phos:4

organism-modification


PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human)
hMYC/iso:1/Phos:4

modification


PR:000002503 c-myc protein isoform 1 unmodified form
MYC/iso:1/UnMod

Yes
organism-modification


PR:000026038 c-myc protein isoform 1 unmodified form (human)
hMYC/iso:1/UnMod

Yes
sequence


PR:000000229 c-myc protein isoform 2
MYC/iso:2

organism-sequence


PR:B2RSN1 c-myc protein isoform 2 (mouse)
mMYC/iso:2
Yes
organism-sequence


PR:P01106-2 c-myc protein isoform 2 (human)
hMYC/iso:2
Yes
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MYC forms found in complexes   

MYC Component
 Complexes
PR:000002503 MYC/iso:1/UnMod PR:000026036 Myc-max complex 1
PR:000026033 hMYC/iso:1/Ac:1 PR:000026035 Myc-max acetylated complex (human)
PR:000026038 hMYC/iso:1/UnMod PR:000026039 Myc-max complex 1 (human)
PR:P01106 hMYC PR:000025987 myc-max complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006357 regulation of transcription by RNA polymerase IIPR:000026051 hMYC/iso:1/OGlyco:1 PMID:11904304
PR:000026052 mMYC/iso:1/Phos:1 PMID:11018017
PR:P01106-1 hMYC/iso:1 PMID:16908182; PMID:2006410
GO:0006879 intracellular iron ion homeostasisPR:000026052 mMYC/iso:1/Phos:1 PMID:11018017
GO:0008283 cell population proliferationPR:000026052 mMYC/iso:1/Phos:1 PMID:11018017
PR:P01106-1 hMYC/iso:1 PMID:10962037
GO:0045766 positive regulation of angiogenesisPR:000026055 hMYC/iso:1/Phos:3 PMID:12676581
GO:0051726 regulation of cell cyclePR:P01106-1 hMYC/iso:1 PMID:10962037

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000026051 hMYC/iso:1/OGlyco:1 PMID:11904304
PR:000026052 mMYC/iso:1/Phos:1 PMID:11018017
GO:0003700 DNA-binding transcription factor activityPR:000026033 hMYC/iso:1/Ac:1 PMID:16126174
contributes_to GO:0003700 DNA-binding transcription factor activityPR:B2RSN1 mMYC/iso:2 PMID:7958908
PR:P01106-1 hMYC/iso:1 PMID:16908182; PMID:2006410
PR:P01106-2 hMYC/iso:2 PMID:3277717
NOT GO:0003700 DNA-binding transcription factor activityPR:000026054 hMYC/iso:1/Phos:2 PMID:7623799
GO:0005515 protein bindingPR:000036448 hMYC/iso:1/Phos:1 PMID:19131971
PR:P01106-1 hMYC/iso:1 PMID:12706874

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000026033 hMYC/iso:1/Ac:1 PMID:16126174
PR:000026052 mMYC/iso:1/Phos:1 PMID:11018017
PR:000026053 mMYC/iso:1/Phos:2 PMID:14563837; PMID:15503302
PR:000026055 hMYC/iso:1/Phos:3 PMID:12676581
PR:P01108-1 mMYC/iso:1 PMID:15503302; PMID:16908182
GO:0005667 transcription factor complexPR:000026033 hMYC/iso:1/Ac:1 PMID:16126174
PR:000026052 mMYC/iso:1/Phos:1 PMID:11018017
PR:B2RSN1 mMYC/iso:2 PMID:7958908
PR:P01106-1 hMYC/iso:1 PMID:16908182; PMID:2006410