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Protein Ontology report - activin receptor type-2B
PR:000000071 - http://purl.obolibrary.org/obo/PR_000000071
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000071   
  PRO nameactivin receptor type-2B 
  Synonyms
PRO-Short-label: EXACT:ACVR2B
Other: EXACT:activin receptor type IIB | ACTR-IIB
  Definition"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2B gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000007 TGF-beta superfamily receptor type-2 with activin receptor domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence5                                                  Organism-Sequence 9                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500456;IUPHARobj:1792
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000071 activin receptor type-2B
ACVR2B
Yes
organism-gene


PR:P27040 activin receptor type-2B (mouse)
mACVR2B

organism-sequence


PR:P27040-1 activin receptor type-2B isoform ActR-IIB1 (mouse)
mACVR2B/iso:ActR-IIB1
Yes
organism-sequence


PR:P27040-2 activin receptor type-2B isoform ActR-IIB2 (mouse)
mACVR2B/iso:ActR-IIB2

organism-modification


PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)
mACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:P27040-3 activin receptor type-2B isoform ActR-IIB3 (mouse)
mACVR2B/iso:ActR-IIB3
Yes
organism-sequence


PR:P27040-4 activin receptor type-2B isoform ActR-IIB4 (mouse)
mACVR2B/iso:ActR-IIB4
Yes
organism-gene


PR:P38445 activin receptor type-2B (rat)
rACVR2B

organism-gene


PR:Q13705 activin receptor type-2B (human)
hACVR2B

organism-sequence


PR:000000214 activin receptor type-2B sequence variant R40H (human)
hACVR2B/var:R40H
Yes
organism-sequence


PR:000000215 activin receptor type-2B sequence variant V494I (human)
hACVR2B/var:V494I
Yes
organism-sequence


PR:Q13705-1 activin receptor type-2B isoform ActR-IIB2 (human)
hACVR2B/iso:ActR-IIB2
Yes
organism-modification


PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:Q13705-2 activin receptor type-2B isoform ActR-IIBtrunc (human)
hACVR2B/iso:ActR-IIB1
Yes
organism-modification


PR:000046259 activin receptor type-2B, signal peptide removed form (human)
hACVR2B/SigPep-

organism-modification


PR:000076998 activin receptor type-2B phosphorylated 1 (human)
hACVR2B/Phos:1

organism-gene


PR:Q90670 activin receptor type-2B (chicken)
chick-ACVR2B

organism-sequence


PR:Q90670-1 activin receptor type-2B isoform ActR-IIB2 (chicken)
chick-ACVR2B/iso:ActR-IIB2

sequence


PR:000000209 activin receptor type-2B isoform ActR-IIB2
ACVR2B/iso:ActR-IIB2

organism-sequence


PR:P27040-2 activin receptor type-2B isoform ActR-IIB2 (mouse)
mACVR2B/iso:ActR-IIB2

organism-modification


PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)
mACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:Q13705-1 activin receptor type-2B isoform ActR-IIB2 (human)
hACVR2B/iso:ActR-IIB2
Yes
organism-modification


PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:Q90670-1 activin receptor type-2B isoform ActR-IIB2 (chicken)
chick-ACVR2B/iso:ActR-IIB2

modification


PR:000000415 activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form
ACVR2B/iso:ActR-IIB2/GlycoPhos+

modification


PR:000000529 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1
ACVR2B/iso:ActR-IIB2/NGlycoPhos:1

organism-modification


PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)
mACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-modification


PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
sequence


PR:000000210 activin receptor type-2B isoform ActR-IIBtrunc
ACVR2B/iso:ActR-IIBtrunc

organism-sequence


PR:Q13705-2 activin receptor type-2B isoform ActR-IIBtrunc (human)
hACVR2B/iso:ActR-IIB1
Yes
sequence


PR:000000211 activin receptor type-2B isoform ActR-IIB1
ACVR2B/iso:ActR-IIB1

organism-sequence


PR:P27040-1 activin receptor type-2B isoform ActR-IIB1 (mouse)
mACVR2B/iso:ActR-IIB1
Yes
sequence


PR:000000212 activin receptor type-2B isoform ActR-IIB3
ACVR2B/iso:ActR-IIB3

organism-sequence


PR:P27040-3 activin receptor type-2B isoform ActR-IIB3 (mouse)
mACVR2B/iso:ActR-IIB3
Yes
sequence


PR:000000213 activin receptor type-2B isoform ActR-IIB4
ACVR2B/iso:ActR-IIB4

organism-sequence


PR:P27040-4 activin receptor type-2B isoform ActR-IIB4 (mouse)
mACVR2B/iso:ActR-IIB4
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathwayPR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8721982
PR:Q13705-1 hACVR2B/iso:ActR-IIB2 PMID:8161782
GO:0009952 anterior/posterior pattern specificationPR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:10452853; PMID:16991118
GO:0032924 activin receptor signaling pathwayPR:000000071 ACVR2B PIRSF:PIRSF500456
GO:0032925 regulation of activin receptor signaling pathwayPR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8721982

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050545 visceral heterotaxyPR:000000214 hACVR2B/var:R40H PMID:9916847
PR:000000215 hACVR2B/var:V494I PMID:9916847

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004675 transmembrane receptor protein serine/threonine kinase activityPR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:1326537
PR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8622651
GO:0005515 protein bindingPR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:11279102; PMID:9872992
GO:0016362 activin receptor activity, type IIPR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8622651
NOT GO:0016362 activin receptor activity, type IIPR:Q13705-2 hACVR2B/iso:ActR-IIB1 PMID:9916847
GO:0019838 growth factor bindingPR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:11459935; PMID:12414726
GO:0048185 activin bindingPR:000000071 ACVR2B PIRSF:PIRSF500456
NOT GO:0050431 transforming growth factor beta bindingPR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:1326537

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8161782
PR:P27040-1 mACVR2B/iso:ActR-IIB1 PMID:1310075
PR:P27040-3 mACVR2B/iso:ActR-IIB3 PMID:1310075
PR:P27040-4 mACVR2B/iso:ActR-IIB4 PMID:1310075
GO:0048179 activin receptor complexPR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 PMID:8622651
PR:P27040-1 mACVR2B/iso:ActR-IIB1 PMID:1310075
PR:P27040-3 mACVR2B/iso:ActR-IIB3 PMID:1310075
PR:P27040-4 mACVR2B/iso:ActR-IIB4 PMID:1310075
SO:0001587 stop_gainedPR:Q13705-2 hACVR2B/iso:ActR-IIB1 PMID:9916847