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Protein Ontology report - TGF-beta receptor-regulated smad protein
PR:000000066 - http://purl.obolibrary.org/obo/PR_000000066
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000066   
  PRO nameTGF-beta receptor-regulated smad protein 
  Synonyms
PRO-Short-label: EXACT:R-SMAD(TGFB)
  Definition"A smad protein that mediates signal transduction through activation of transforming growth factor beta (TGF-beta) or activin pathways." [PMID:11532220] 
  PRO Categoryfamily 
  ParentPR:000000027 smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 9                                        
         Sequence3                                                  Organism-Sequence 16                                        
         Modification28                                                  Organism-Modification 52                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500455
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000066 TGF-beta receptor-regulated smad protein
R-SMAD(TGFB)
Yes
gene


PR:000000364 smad2
SMAD2

organism-gene


PR:O70436 mothers against decapentaplegic homolog 2 (rat)
rSMAD2

organism-gene


PR:P45896 dwarfin sma-3 (worm)
SMAD2 (worm)

organism-gene


PR:Q15796 mothers against decapentaplegic homolog 2 (human)
hSMAD2

organism-sequence


PR:000000470 smad2 sequence variant R133C (human)
hSMAD2/var:R133C
Yes
organism-sequence


PR:000000471 smad2 sequence variant L440R (human)
hSMAD2/var:L440R
Yes
organism-sequence


PR:000000472 smad2 sequence variant P445H (human)
hSMAD2/var:P445H
Yes
organism-sequence


PR:000000473 smad2 sequence variant D450E (human)
hSMAD2/var:D450E
Yes
organism-sequence


PR:000000474 smad2 sequence variant 5 (human)
hSMAD2/var:5
Yes
organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000025960 smad2 isoform unphosphorylated 1 (human)
hSMAD2/iso:[Long/Short]/UnPhos:1

organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1

organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human)
hSMAD2/InitMet-

organism-modification


PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human)
hSMAD2/InitMet-/Phos:1

organism-modification


PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human)
hSMAD2/InitMet-/Phos:5

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000060357 mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300A/InitMet-/Phos:1

organism-modification


PR:000060522 mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human)
hSMAD2/var:S464L/InitMet-

organism-modification


PR:000060657 mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300V/InitMet-/Phos:1

organism-modification


PR:000060862 mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300N/InitMet-/Phos:1

organism-modification


PR:000061944 mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:A354T/InitMet-/Phos:1

organism-modification


PR:000062120 mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305Q/InitMet-/Phos:1

organism-modification


PR:000062419 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human)
hSMAD2/InitMet-/Phos:2

organism-modification


PR:000063661 mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human)
hSMAD2/var:S464*/InitMet-

organism-modification


PR:000063912 mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human)
hSMAD2/var:S467P/InitMet-

organism-modification


PR:000064349 mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305L/InitMet-/Phos:1

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000050145 smad2 phosphorylated 1 (human)
hSMAD2/Phos:1

organism-modification


PR:000065797 mothers against decapentaplegic homolog 2 methylated 1 (human)
hSMAD2/Me:1

organism-modification


PR:000077056 mothers against decapentaplegic homolog 2 cysteinylated 1 (human)
hSMAD2/Cyst:1

organism-gene


PR:Q62432 mothers against decapentaplegic homolog 2 (mouse)
mSMAD2

organism-sequence


PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse)
mSMAD2/iso:Long
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-sequence


PR:Q62432-2 mothers against decapentaplegic homolog 2 isoform Short (mouse)
mSMAD2/iso:Short

organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
organism-gene


PR:Q9I9P9 mothers against decapentaplegic homolog 2 (zebrafish)
z-SMAD2

sequence


PR:000000468 smad2 isoform Long
SMAD2/iso:Long

organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse)
mSMAD2/iso:Long
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000572 smad2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+

modification


PR:000000649 smad2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 smad2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 smad2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000574 smad2 isoform Long phosphorylated form
SMAD2/iso:Long/PhosRes+

modification


PR:000000572 smad2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+

modification


PR:000000649 smad2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 smad2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 smad2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000650 smad2 isoform Long phosphorylated 1
SMAD2/iso:Long/Phos:1

Yes
organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
modification


PR:000000651 smad2 isoform Long phosphorylated 2
SMAD2/iso:Long/Phos:2

Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
modification


PR:000000652 smad2 isoform Long phosphorylated 3
SMAD2/iso:Long/Phos:3

Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
modification


PR:000000653 smad2 isoform Long phosphorylated 4
SMAD2/iso:Long/Phos:4

organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
modification


PR:000002570 smad2 isoform Long unmodified form
SMAD2/iso:Long/UnMod

Yes
modification


PR:000026718 smad2 isoform Long, initiator methionine removed form
SMAD2/iso:Long/InitMet-

sequence


PR:000000469 smad2 isoform Short
SMAD2/iso:Short

organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-sequence


PR:Q62432-2 mothers against decapentaplegic homolog 2 isoform Short (mouse)
mSMAD2/iso:Short

organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form
SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1
SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000576 smad2 isoform Short phosphorylated form
SMAD2/iso:Short/PhosRes+

modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form
SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1
SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000656 smad2 isoform Short phosphorylated 1
SMAD2/iso:Short/Phos:1

Yes
organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000002571 smad2 isoform Short unmodified form
SMAD2/iso:Short/UnMod

modification


PR:000018296 smad2, initiator methionine removed form
SMAD2/InitMet-

modification


PR:000026718 smad2 isoform Long, initiator methionine removed form
SMAD2/iso:Long/InitMet-

organism-modification


PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human)
hSMAD2/InitMet-

organism-modification


PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human)
hSMAD2/InitMet-/Phos:1

organism-modification


PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human)
hSMAD2/InitMet-/Phos:5

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000060357 mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300A/InitMet-/Phos:1

organism-modification


PR:000060522 mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human)
hSMAD2/var:S464L/InitMet-

organism-modification


PR:000060657 mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300V/InitMet-/Phos:1

organism-modification


PR:000060862 mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300N/InitMet-/Phos:1

organism-modification


PR:000061944 mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:A354T/InitMet-/Phos:1

organism-modification


PR:000062120 mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305Q/InitMet-/Phos:1

organism-modification


PR:000062419 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human)
hSMAD2/InitMet-/Phos:2

organism-modification


PR:000063661 mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human)
hSMAD2/var:S464*/InitMet-

organism-modification


PR:000063912 mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human)
hSMAD2/var:S467P/InitMet-

organism-modification


PR:000064349 mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305L/InitMet-/Phos:1

modification


PR:000028327 smad2 unmodified form
SMAD2/UnMod

modification


PR:000002570 smad2 isoform Long unmodified form
SMAD2/iso:Long/UnMod

Yes
modification


PR:000002571 smad2 isoform Short unmodified form
SMAD2/iso:Short/UnMod

modification


PR:000025973 smad2 isoform unmodified form
SMAD2/iso:[Long/Short]/UnMod

Yes
modification


PR:000002570 smad2 isoform Long unmodified form
SMAD2/iso:Long/UnMod

modification


PR:000002571 smad2 isoform Short unmodified form
SMAD2/iso:Short/UnMod

modification


PR:000050146 smad2 phosphorylated 1
SMAD2/Phos:1

organism-modification


PR:000050145 smad2 phosphorylated 1 (human)
hSMAD2/Phos:1

gene


PR:000000365 smad3
SMAD3

organism-gene


PR:P84022 mothers against decapentaplegic homolog 3 (human)
hSMAD3

organism-sequence


PR:000062539 mothers against decapentaplegic homolog 3 sequence variant S425F (human)
hSMAD3/var:S425F

organism-sequence


PR:000063486 mothers against decapentaplegic homolog 3 sequence variant S425C (human)
hSMAD3/var:S425C

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human)
hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:P84022-2 mothers against decapentaplegic homolog 3 isoform h2 (human)
hSMAD3/iso:h2

organism-sequence


PR:P84022-3 mothers against decapentaplegic homolog 3 isoform h3 (human)
hSMAD3/iso:h3

organism-sequence


PR:P84022-4 mothers against decapentaplegic homolog 3 isoform h4 (human)
hSMAD3/iso:h4

organism-modification


PR:000049285 mothers against decapentaplegic homolog 3 phosphorylated 1 (human)
hSMAD3/Phos:1

organism-modification


PR:000049286 mothers against decapentaplegic homolog 3 phosphorylated 2 (human)
hSMAD3/Phos:2

organism-modification


PR:000049287 mothers against decapentaplegic homolog 3 ubiquitinated form (human)
hSMAD3/UbiqLys+

organism-modification


PR:000064859 mothers against decapentaplegic homolog 3 phosphorylated and ubiquitinated 1 (human)
hSMAD3/PhosUbiq:1

organism-modification


PR:000060563 mothers against decapentaplegic homolog 3 sequence variant R268H phosphorylated 1 (human)
hSMAD3/var:R268H/Phos:1

organism-modification


PR:000061858 mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human)
hSMAD3/ADPribPhos:1

organism-modification


PR:000063368 mothers against decapentaplegic homolog 3 phosphorylated 3 (human)
hSMAD3/Phos:3

organism-modification


PR:000063580 mothers against decapentaplegic homolog 3 sequence variant R268C phosphorylated 1 (human)
hSMAD3/var:R268C/Phos:1

organism-modification


PR:000063639 mothers against decapentaplegic homolog 3 sequence variant D258N phosphorylated 1 (human)
hSMAD3/var:D258N/Phos:1

organism-modification


PR:000065228 mothers against decapentaplegic homolog 3 deaminated 1 (human)
hSMAD3/Deam:1

organism-modification


PR:000065534 mothers against decapentaplegic homolog 3 methylated 1 (human)
hSMAD3/Me:1

organism-modification


PR:000073148 mothers against decapentaplegic homolog 3 cysteinylated 1 (human)
hSMAD3/Cyst:1

organism-modification


PR:000074741 mothers against decapentaplegic homolog 3 methylated 2 (human)
hSMAD3/Me:2

organism-gene


PR:P84023 mothers against decapentaplegic homolog 3 (chicken)
chick-SMAD3

organism-gene


PR:P84025 mothers against decapentaplegic homolog 3 (rat)
rSMAD3

organism-gene


PR:Q8BUN5 mothers against decapentaplegic homolog 3 (mouse)
mSMAD3

organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse)
mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
sequence


PR:000000475 smad3 isoform 1
SMAD3/iso:1

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human)
hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse)
mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form
SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1
SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000578 smad3 isoform 1 phosphorylated form
SMAD3/iso:1/PhosRes+

modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form
SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1
SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000658 smad3 isoform 1 phosphorylated 1
SMAD3/iso:1/Phos:1

organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
modification


PR:000000659 smad3 isoform 1 phosphorylated 2
SMAD3/iso:1/Phos:2

organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
modification


PR:000000660 smad3 isoform 1 phosphorylated 3
SMAD3/iso:1/Phos:3

organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
modification


PR:000027744 TGF-beta receptor-regulated smad protein unmodified form
R-SMAD(TGFB)/UnMod

organism-modification


PR:000027745 TGF-beta receptor-regulated smad protein unmodified form (human)
hR-SMAD(TGFB)/UnMod

modification


PR:000027746 TGF-beta receptor-regulated smad protein phosphorylated form
R-SMAD(TGFB)/PhosRes+

organism-modification


PR:000027747 TGF-beta receptor-regulated smad protein phosphorylated form (human)
hR-SMAD(TGFB)/PhosRes+

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R-SMAD(TGFB) forms found in complexes   

R-SMAD(TGFB) Component
 Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025971 smad2-smad4-ski protein complex 1
PR:000000651 SMAD2/iso:Long/Phos:2 PR:000025969 smad2-smad4 protein complex 3
PR:000000652 SMAD2/iso:Long/Phos:3 PR:000025970 smad2-smad4 protein complex 4
PR:000000656 SMAD2/iso:Short/Phos:1 PR:000025968 smad2-smad4 protein complex 2
PR:000002570 SMAD2/iso:Long/UnMod PR:000025972 smad2-smad4-ski protein complex 2
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000025943 mSMAD2/iso:Short/Phos:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
PR:000025973 SMAD2/iso:[Long/Short]/UnMod PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:15690394; PMID:9689110
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
GO:0006366 transcription by RNA polymerase IIPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886
GO:0007165 signal transductionPR:000000470 hSMAD2/var:R133C PMID:8752209
PR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11262418
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1 PMID:15496141
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000000066 R-SMAD(TGFB) PIRSF:PIRSF500455
PR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228
PR:000025938 hSMAD2/iso:Short/Phos:1 PMID:9873005
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11262418
PR:000025943 mSMAD2/iso:Short/Phos:1 PMID:15630024
PR:000026333 hSMAD3/iso:1/Phos:1 PMID:8774881; PMID:9380693
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
PR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:8752209
PR:P84022-1 hSMAD3/iso:1 PMID:8774881
PR:Q62432-1 mSMAD2/iso:Long PMID:11557747
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12543979
GO:0060395 SMAD protein signal transductionPR:000000066 R-SMAD(TGFB) PIRSF:PIRSF500455
PR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:5672 large intestine cancerPR:000000470 hSMAD2/var:R133C PMID:8752209
PR:000000471 hSMAD2/var:L440R PMID:8752209
PR:000000472 hSMAD2/var:P445H PMID:8752209
PR:000000473 hSMAD2/var:D450E PMID:8752209
PR:000000474 hSMAD2/var:5 PMID:8673135

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8980228; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886; PMID:12943993
GO:0003677 DNA bindingPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:14701940; PMID:9873005
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
GO:0003690 double-stranded DNA bindingPR:000036558 mSMAD3/iso:1/Phos:1 PMID:15282343
GO:0003700 DNA-binding transcription factor activityPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:9873005
PR:000025943 mSMAD2/iso:Short/Phos:1 PMID:15630024
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
PR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:10823886; PMID:12943993
PR:000036560 mSMAD3/iso:1/Phos:2 PMID:15241418
GO:0003712 transcription coregulator activityPR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025938 hSMAD2/iso:Short/Phos:1 PMID:14701940; PMID:9873005
GO:0003713 transcription coactivator activityPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9689110
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:15282343
NOT GO:0003713 transcription coactivator activityPR:000000470 hSMAD2/var:R133C PMID:8752209
PR:000000472 hSMAD2/var:P445H PMID:8752209
PR:000000473 hSMAD2/var:D450E PMID:8752209
PR:000000474 hSMAD2/var:5 PMID:8673135
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4 PMID:10197981
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1 PMID:15496141
PR:000036561 mSMAD3/iso:1/Phos:3 PMID:10197981
GO:0005515 protein bindingPR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:8980228
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
GO:0008134 transcription factor bindingPR:000026333 hSMAD3/iso:1/Phos:1 PMID:15084259
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15464984; PMID:9702197
GO:0046332 SMAD bindingPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9311995
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11043574
PR:000026333 hSMAD3/iso:1/Phos:1 PMID:15350224; PMID:9311995

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595; PMID:17074053
PR:000025942 mSMAD2/iso:Long/Phos:1 PMID:11557747
PR:000026333 hSMAD3/iso:1/Phos:1 PMID:10846168; PMID:15280432
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
PR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:12943993; PMID:15282343
GO:0005667 transcription factor complexPR:000026333 hSMAD3/iso:1/Phos:1 PMID:12374795
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:9702197
GO:0005737 cytoplasmPR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4 PMID:10197981
PR:000036561 mSMAD3/iso:1/Phos:3 PMID:10197981
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:15280432; PMID:17074053
PR:P84022-1 hSMAD3/iso:1 PMID:17074053
PR:Q62432-1 mSMAD2/iso:Long PMID:14701940
GO:0005769 early endosomePR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:12356868