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Protein Ontology report - BMP receptor type-1B
PR:000000036 - http://purl.obolibrary.org/obo/PR_000000036
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000036   
  PRO nameBMP receptor type-1B 
  Synonyms
PRO-Short-label: EXACT:BMPR1B
Gene-based: RELATED:Acvrlk6
Other: EXACT:activin receptor-like kinase 6 | ALK-6 | BMP type-1B receptor | BMPR-1B | CDw293 | serine/threonine-protein kinase receptor R6 | SKR6
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1B gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1789
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000036 BMP receptor type-1B
BMPR1B

organism-gene


PR:O00238 bone morphogenetic protein receptor type-1B (human)
hBMPR1B

organism-sequence


PR:000000146 BMP receptor type-1B sequence variant I200K (human)
hBMPR1B/var:I200K
Yes
organism-sequence


PR:000000147 BMP receptor type-1B sequence variant R486W (human)
hBMPR1B/var:R486W
Yes
organism-sequence


PR:O00238-1 bone morphogenetic protein receptor type-1B isoform 1 (human)
hBMPR1B/iso:1
Yes
organism-modification


PR:000036426 BMP receptor type-1B isoform 1 phosphorylated 1 (human)
hBMPR1B/iso:1/Phos:1
Yes
organism-sequence


PR:O00238-2 bone morphogenetic protein receptor type-1B isoform h2 (human)
hBMPR1B/iso:h2

organism-modification


PR:000046495 bone morphogenetic protein receptor type-1B, signal peptide removed form (human)
hBMPR1B/SigPep-

organism-modification


PR:000046496 bone morphogenetic protein receptor type-1B, signal peptide removed phosphoserine(4+) form (human)
hBMPR1B/SigPep-/PhosSer(4+)

organism-gene


PR:P36898 bone morphogenetic protein receptor type-1B (mouse)
mBMPR1B

organism-sequence


PR:P36898-1 bone morphogenetic protein receptor type-1B isoform 1 (mouse)
mBMPR1B/iso:1
Yes
organism-modification


PR:000036425 BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)
mBMPR1B/iso:1/Phos:1
Yes
organism-gene


PR:Q05438 bone morphogenetic protein receptor type-1B (chicken)
chick-BMPR1B

organism-gene


PR:Q09488 serine/threonine-protein kinase receptor sma-6 (worm)
BMPR1B (worm)

organism-gene


PR:Q569A5 receptor protein serine/threonine kinase (rat)
rBMPR1B

sequence


PR:000000145 BMP receptor type-1B isoform 1
BMPR1B/iso:1

organism-sequence


PR:O00238-1 bone morphogenetic protein receptor type-1B isoform 1 (human)
hBMPR1B/iso:1
Yes
organism-modification


PR:000036426 BMP receptor type-1B isoform 1 phosphorylated 1 (human)
hBMPR1B/iso:1/Phos:1
Yes
organism-sequence


PR:P36898-1 bone morphogenetic protein receptor type-1B isoform 1 (mouse)
mBMPR1B/iso:1
Yes
organism-modification


PR:000036425 BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)
mBMPR1B/iso:1/Phos:1
Yes
modification


PR:000000383 BMP receptor type-1B isoform 1 phosphorylated form
BMPR1B/iso:1/PhosRes+

modification


PR:000000500 BMP receptor type-1B isoform 1 phosphorylated 1
BMPR1B/iso:1/Phos:1

organism-modification


PR:000036425 BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)
mBMPR1B/iso:1/Phos:1
Yes
organism-modification


PR:000036426 BMP receptor type-1B isoform 1 phosphorylated 1 (human)
hBMPR1B/iso:1/Phos:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000146 hBMPR1B/var:I200K
Example: UniProtKB:O00238-1, Ile-200, CHEBI:29967		 associated_with_disease_progressionDO:0050581 brachydactyly PMID:14523231
enablesNOT GO:0004674 protein serine/threonine kinase activity PMID:14523231
located_inGO:0009986 cell surface PMID:14523231
PR:000000147 hBMPR1B/var:R486W
Example: UniProtKB:O00238-1, Arg-486, CHEBI:29954		 associated_with_disease_progressionDO:0050581 brachydactyly PMID:14523231
enablesGO:0004674 protein serine/threonine kinase activity PMID:14523231
located_inGO:0009986 cell surface PMID:14523231
PR:000036425 mBMPR1B/iso:1/Phos:1 acts_upstream_of_or_withinGO:0001501 skeletal system development PMID:14523231
GO:0001502 cartilage condensation PMID:10631181; PMID:14523231
GO:0035108 limb morphogenesis PMID:14523231
located_inGO:0009986 cell surface PMID:10712517; PMID:14523231
GO:0043235 receptor complex PMID:10712517
PR:000036426 hBMPR1B/iso:1/Phos:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:10051328
GO:0045597 positive regulation of cell differentiation PMID:14523231
PR:O00238-1 hBMPR1B/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:10051328
PR:P36898-1 mBMPR1B/iso:1 acts_upstream_of_or_withinGO:0001501 skeletal system development PMID:14523231
GO:0001502 cartilage condensation PMID:14523231
GO:0035108 limb morphogenesis PMID:14523231
located_inGO:0009986 cell surface PMID:10712517