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Protein Ontology report - retinoblastoma-like protein
PR:000000023 - http://purl.obolibrary.org/obo/PR_000000023
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000023   
  PRO nameretinoblastoma-like protein 
  Definition"A protein that has a core domain composition consisting of a Retinoblastoma-associated protein A domain (Pfam:PF01858) followed by a Retinoblastoma-associated protein B domain (Pfam:PF01857). The retinoblastoma-like proteins are key regulators of entry into cell division. They are directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 7                                        
         Sequence4                                                  Organism-Sequence 7                                        
         Modification6                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037408
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000023
retinoblastoma-like protein
NOG
"A protein that has a core domain composition consisting of a Retinoblastoma-associated protein A domain (Pfam:PF01858) followed by a Retinoblastoma-associated protein B domain (Pfam:PF01857). The retinoblastoma-like proteins are key regulators of entry into cell division. They are directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation." [PRO:CNA]
Yes
gene


PR:000000118
retinoblastoma-like protein 1
RBL1
"A retinoblastoma-like protein that is a translation product of the human RBL1 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:D3ZS28
retinoblastoma-like protein 1 (rat)
rRBL1
"A retinoblastoma-like protein 1 that is encoded in the genome of rat." [OMA:D3ZS28, PRO:DNx]

organism-gene


PR:P28749
retinoblastoma-like protein 1 (human)
hRBL1
"A retinoblastoma-like protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28749]

organism-sequence


PR:P28749-1
retinoblastoma-like protein 1 isoform 1 (human)
hRBL1/iso:1
"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036470
retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)
hRBL1/iso:1/Phos:1
"A retinoblastoma-like protein 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA]
Yes
organism-sequence


PR:P28749-2
retinoblastoma-like protein 1 isoform 2 (human)
hRBL1/iso:2
"A retinoblastoma-like protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000049024
retinoblastoma-like protein 1 phosphorylated 1 (human)
hRBL1/Phos:1
"A retinoblastoma-like protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-369, and phosphoserine at positions 640, 964 and 975 of the amino acid sequence represented by UniProtKB:P28749. UniProtKB:P28749, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PRO:DNx, Reactome:R-HSA-1226085]

organism-gene


PR:Q24472
retinoblastoma family protein (fruit fly)
fly-RBL1
"A retinoblastoma-like protein 1 that is encoded in the genome of fruit fly." [PRO:CNA]

organism-gene


PR:Q64701
retinoblastoma-like protein 1 (mouse)
mRBL1
"A retinoblastoma-like protein 1 that is encoded in the genome of mouse." [OMA:Q64701, PRO:DNx]

organism-sequence


PR:Q64701-1
retinoblastoma-like protein 1 isoform Long (mouse)
mRBL1/iso:Long
"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-sequence


PR:Q64701-2
retinoblastoma-like protein 1 isoform Short (mouse)
mRBL1/iso:Short
"A retinoblastoma-like protein 1 isoform 3 that is encoded in the genome of mouse." [PRO:CNA]

sequence


PR:000000303
retinoblastoma-like protein 1 isoform 1
RBL1/iso:1
"A retinoblastoma-like protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28749-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P28749-1
retinoblastoma-like protein 1 isoform 1 (human)
hRBL1/iso:1
"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036470
retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)
hRBL1/iso:1/Phos:1
"A retinoblastoma-like protein 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA]
Yes
organism-sequence


PR:Q64701-1
retinoblastoma-like protein 1 isoform Long (mouse)
mRBL1/iso:Long
"A retinoblastoma-like protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000000458
retinoblastoma-like protein 1 isoform 1 phosphorylated form
RBL1/iso:1/PhosRes+
"A retinoblastoma-like protein 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000559
retinoblastoma-like protein 1 isoform 1 phosphorylated 1
RBL1/iso:1/Phos:1
"A retinoblastoma-like protein 1 isoform 1 phosphorylated form in which the phosphorylation occurs in an RxL motif-dependent fashion by cyclin Cdk4. Example: UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA, PRO:DAN]

organism-modification


PR:000036470
retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)
hRBL1/iso:1/Phos:1
"A retinoblastoma-like protein 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046." [PMID:11884610, PRO:CNA]
Yes
sequence


PR:000000304
retinoblastoma-like protein 1 isoform 2
RBL1/iso:2
"A retinoblastoma-like protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28749-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P28749-2
retinoblastoma-like protein 1 isoform 2 (human)
hRBL1/iso:2
"A retinoblastoma-like protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]

sequence


PR:000000305
retinoblastoma-like protein 1 isoform 3
RBL1/iso:3
"A retinoblastoma-like protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64701-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q64701-2
retinoblastoma-like protein 1 isoform Short (mouse)
mRBL1/iso:Short
"A retinoblastoma-like protein 1 isoform 3 that is encoded in the genome of mouse." [PRO:CNA]

gene


PR:000000119
retinoblastoma-like protein 2
RBL2
"A retinoblastoma-like protein that is a translation product of the human RBL2 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:O55081
retinoblastoma-like protein 2 (rat)
rRBL2
"A retinoblastoma-like protein 2 that is encoded in the genome of rat." [OMA:O55081, PRO:DNx]

organism-gene


PR:Q08999
retinoblastoma-like protein 2 (human)
hRBL2
"A retinoblastoma-like protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q08999]

organism-sequence


PR:Q08999-1
retinoblastoma-like protein 2 isoform 1 (human)
hRBL2/iso:1
"A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036471
retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-modification


PR:000036472
retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 2 in human. UniProtKB:Q08999-1, Ser-672, MOD:00046." [PMID:12006580, PRO:CNA]
Yes
organism-modification


PR:000036473
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in human. UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-sequence


PR:Q08999-2
retinoblastoma-like protein 2 isoform h2 (human)
hRBL2/iso:h2
"A retinoblastoma-like protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08999-2." [PRO:DNx, UniProtKB:Q08999]

organism-modification


PR:000049025
retinoblastoma-like protein 2 phosphorylated 4 (human)
hRBL2/Phos:4
"A retinoblastoma-like protein 2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-401, and phosphoserine at positions 672 and 1035 of the amino acid sequence represented by UniProtKB:Q08999. UniProtKB:Q08999, Thr-401, MOD:00047|Ser-672/Ser-1035, MOD:00046." [PRO:DNx, Reactome:R-HSA-1226084]

organism-modification


PR:000068308
retinoblastoma-like protein 2 phosphorylated 1 (human)
hRBL2/Phos:1
"A retinoblastoma-like protein 2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-401 of the amino acid sequence represented by UniProtKB:Q08999-1. Example: UniProtKB:Q08999-1, Thr-401, MOD:00047." [IEDB_epitope:1368331, PRO:DNx]

organism-gene


PR:Q64700
retinoblastoma-like protein 2 (mouse)
mRBL2
"A retinoblastoma-like protein 2 that is encoded in the genome of mouse." [OMA:Q64700, PRO:DNx]

organism-sequence


PR:Q64700-1
retinoblastoma-like protein 2 isoform 1 (mouse)
mRBL2/iso:1
"A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036474
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in mouse." [PMID:10082561, PRO:CNA]
Yes
sequence


PR:000000306
retinoblastoma-like protein 2 isoform 1
RBL2/iso:1
"A retinoblastoma-like protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08999-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q08999-1
retinoblastoma-like protein 2 isoform 1 (human)
hRBL2/iso:1
"A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036471
retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-modification


PR:000036472
retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 2 in human. UniProtKB:Q08999-1, Ser-672, MOD:00046." [PMID:12006580, PRO:CNA]
Yes
organism-modification


PR:000036473
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in human. UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-sequence


PR:Q64700-1
retinoblastoma-like protein 2 isoform 1 (mouse)
mRBL2/iso:1
"A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036474
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in mouse." [PMID:10082561, PRO:CNA]
Yes
modification


PR:000000459
retinoblastoma-like protein 2 isoform 1 phosphorylated form
RBL2/iso:1/PhosRes+
"A retinoblastoma-like protein 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000560
retinoblastoma-like protein 2 isoform 1 phosphorylated 1
RBL2/iso:1/Phos:1
"A retinoblastoma-like protein 2 isoform 1 phosphorylated form in which the phosphorylation occurs during Go/G1-S phase progression. Example: UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PRO:CNA, PRO:DAN]

organism-modification


PR:000036471
retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
modification


PR:000000561
retinoblastoma-like protein 2 isoform 1 phosphorylated 2
RBL2/iso:1/Phos:2
"A retinoblastoma-like protein 2 isoform 1 phosphorylated form that has Cdk-dependent G1 phosphorylation, and additionally phosphorylated on a Ser residue within the region linking the retinoblastoma-associated protein A and B domains, by cyclin Cdk4(6). This phosphorylation leads to ubiquitin-dependent proteolysis." [PMID:12006580, PMID:12435635]

organism-modification


PR:000036472
retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 2 in human. UniProtKB:Q08999-1, Ser-672, MOD:00046." [PMID:12006580, PRO:CNA]
Yes
modification


PR:000000562
retinoblastoma-like protein 2 isoform 1 phosphorylated 3
RBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 that has been phosphorylated on residues at positions equivalent to Ser-639, Ser-952, Ser-966, Ser-971, Ser-972, Ser-973, Thr-974, Ser-981, Ser-982, and Thr-986 of the amino acid sequence represented by UniProtKB:Q08999-1 or a 1:1 ortholog thereof. Example: UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PRO:CNA, PRO:DAN]

organism-modification


PR:000036473
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in human. UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-modification


PR:000036474
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in mouse." [PMID:10082561, PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0051726 regulation of cell cyclePR:000000023 NOG PIRSF:PIRSF037408
PR:000036470 hRBL1/iso:1/Phos:1 PMID:11884610
PR:000036471 hRBL2/iso:1/Phos:1 PMID:11042701; PMID:11157749; PMID:8710362
PR:000036472 hRBL2/iso:1/Phos:2 PMID:12006580
PR:000036473 hRBL2/iso:1/Phos:3 PMID:11042701; PMID:11157749; PMID:8710362
PR:P28749-1 hRBL1/iso:1 PMID:8319904
PR:Q64700-1 mRBL2/iso:1 PMID:10082561

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515 protein bindingPR:000000023 NOG PIRSF:PIRSF037408
PR:000036470 hRBL1/iso:1/Phos:1 PMID:11884610
PR:000036472 hRBL2/iso:1/Phos:2 PMID:12006580
PR:000036473 hRBL2/iso:1/Phos:3 PMID:11042701; PMID:11157749
PR:P28749-1 hRBL1/iso:1 PMID:11884610
PR:Q08999-1 hRBL2/iso:1 PMID:8361765
NOT GO:0005515 protein bindingPR:000036471 hRBL2/iso:1/Phos:1 PMID:11157749
GO:0030308 negative regulation of cell growthPR:P28749-1 hRBL1/iso:1 PMID:11884610
PR:Q64700-1 mRBL2/iso:1 PMID:10082561
NOT GO:0030308 negative regulation of cell growthPR:000036470 hRBL1/iso:1/Phos:1 PMID:11884610
PR:000036471 hRBL2/iso:1/Phos:1 PMID:11157749
PR:000036472 hRBL2/iso:1/Phos:2 PMID:12006580

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:Q64700-1 mRBL2/iso:1 PMID:10082561
GO:0005667 transcription factor complexPR:000036474 mRBL2/iso:1/Phos:3 PMID:10082561