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Protein Ontology report - anti-Muellerian hormone type-2 receptor
PR:000000009 - http://purl.obolibrary.org/obo/PR_000000009
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000009   
  PRO nameanti-Muellerian hormone type-2 receptor 
  Synonyms
PRO-Short-label: EXACT:AMHR2
Gene-based: RELATED:AMHR | MISR2
Other: EXACT:AMH type II receptor | anti-Muellerian hormone type II receptor | MIS type II receptor | MISRII | MRII
  Definition"A protein that is a translation product of the human AMHR2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 15                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1793
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000009

anti-Muellerian hormone type-2 receptor

AMHR2


"A protein that is a translation product of the human AMHR2 gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:Q16671

anti-Muellerian hormone type-2 receptor (human)

hAMHR2


"An anti-Muellerian hormone type-2 receptor that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16671]


organism-sequence



PR:000000075

anti-Muellerian hormone type-2 receptor sequence variant R54C (human)

hAMHR2/var:R54C


"An anti-Muellerian hormone type-2 receptor (human) that has a Cys residue at the position equivalent to Arg-54 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, Arg-54, CHEBI:29950." [PMID:8872466, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000076

anti-Muellerian hormone type-2 receptor sequence variant G142V (human)

hAMHR2/var:G142V


"An anti-Muellerian hormone type-2 receptor (human) that has a Val residue at the position equivalent to Gly-142 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, Gly-142, CHEBI:30015." [PMID:8872466, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000077

anti-Muellerian hormone type-2 receptor sequence variant H282Q (human)

hAMHR2/var:H282Q


"An anti-Muellerian hormone type-2 receptor (human) that has a Gln residue at the position equivalent to His-282 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, His-282, CHEBI:30011." [PMID:8872466, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000078

anti-Muellerian hormone type-2 receptor sequence variant R406Q (human)

hAMHR2/var:R406Q


"An anti-Muellerian hormone type-2 receptor (human) that has a Gln residue at the position equivalent to Arg-406 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, Arg-406, CHEBI:30011." [PMID:11549681, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000079

anti-Muellerian hormone type-2 receptor sequence variant D426G (human)

hAMHR2/var:D426G


"An anti-Muellerian hormone type-2 receptor (human) that has a Gly residue at the position equivalent to Asp-426 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, Asp-426, CHEBI:29947." [PMID:8872466, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000080

anti-Muellerian hormone type-2 receptor sequence variant V458A (human)

hAMHR2/var:V458A


"An anti-Muellerian hormone type-2 receptor (human) that has an Ala residue at the position equivalent to Val-458 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, Val-458, CHEBI:46217." [PMID:8872466, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000081

anti-Muellerian hormone type-2 receptor sequence variant D491H (human)

hAMHR2/var:D491H


"An anti-Muellerian hormone type-2 receptor (human) that has a His residue at the position equivalent to Asp-491 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, Asp-491, CHEBI:29979." [PMID:8872466, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000082

anti-Muellerian hormone type-2 receptor sequence variant R504C (human)

hAMHR2/var:R504C


"An anti-Muellerian hormone type-2 receptor (human) that has a Cys residue at the position equivalent to Arg-504 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, Arg-504, CHEBI:29950." [PMID:8872466, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000083

anti-Muellerian hormone type-2 receptor sequence variant 9 (human)

hAMHR2/var:9


"An anti-Muellerian hormone type-2 receptor (human) that has a nine-residue deletion at the position equivalent to region 444-452 of the amino acid sequence represented by UniProtKB:Q16671-1. Example: UniProtKB:Q16671-1, 18-443, 453-573." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q16671-1

anti-Muellerian hormone type-2 receptor isoform 1 (human)

hAMHR2/iso:1


"An anti-Muellerian hormone type-2 receptor isoform 1 that is encoded in the genome of human." [PMID:10589763, PRO:CNA]

Yes

organism-sequence



PR:Q16671-2

anti-Muellerian hormone type-2 receptor isoform h2 (human)

hAMHR2/iso:h2


"An anti-Muellerian hormone type-2 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16671-2." [PRO:DNx, UniProtKB:Q16671]


organism-sequence



PR:Q16671-3

anti-Muellerian hormone type-2 receptor isoform Delta9/10 (human)

hAMHR2/iso:Delta9/10


"An anti-Muellerian hormone type-2 receptor isoform Delta9/10 that is encoded in the genome of human. This sequence lacks the region encoded by exons 9 and 10, which is part of the protein kinase domain." [PRO:CNA, UniProtKB:Q16671-3]


organism-modification



PR:000063671

anti-Muellerian hormone type-2 receptor, signal peptide removed form (human)

hAMHR2/SigPep-


"An anti-Muellerian hormone type-2 receptor (human) that has had the signal peptide removed. Example: UniProtKB:Q16671-1, 18-573." [PRO:DNx, Reactome:R-HSA-8858258]


organism-gene



PR:Q62893

anti-Muellerian hormone type-2 receptor (rat)

rAMHR2


"An anti-Muellerian hormone type-2 receptor that is encoded in the genome of rat." [OMA:Q62893, PRO:DNx]


organism-gene



PR:Q8K592

anti-Muellerian hormone type-2 receptor (mouse)

mAMHR2


"An anti-Muellerian hormone type-2 receptor that is encoded in the genome of mouse." [OMA:Q8K592, PRO:CNA]


organism-sequence



PR:Q8K592-1

anti-Muellerian hormone type-2 receptor isoform 1 (mouse)

mAMHR2/iso:1


"An anti-Muellerian hormone type-2 receptor isoform 1 that is encoded in the genome of mouse." [PMID:23624077, PMID:9299437, PRO:HJD]

Yes

organism-sequence



PR:R4JKA2

anti-Muellerian hormone type-2 receptor isoform Delta2 (mouse)

mAMHR2/iso:Delta2


"An anti-Muellerian hormone type-2 receptor isoform Delta2 that is encoded in the genome of mouse. This sequence lacks the region encoded by exon 2 which is part of the extracellular domain and it is essential for ligand binding." [EMBL:KC920727, PMID:23624077, PRO:HJD]

Yes

organism-sequence



PR:R4JNM3

anti-Muellerian hormone type-2 receptor isoform Delta9/10 (mouse)

mAMHR2/iso:Delta9/10


"An anti-Muellerian hormone type-2 receptor isoform Delta9/10 that is encoded in the genome of mouse. This sequence lacks the region encoded by exons 9 and 10, which is part of the protein kinase domain." [EMBL:KC920726, PMID:23624077, PRO:HJD]

Yes

sequence



PR:000000074

anti-Muellerian hormone type-2 receptor isoform 1

AMHR2/iso:1


"An anti-Muellerian hormone type-2 receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16671-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q16671-1

anti-Muellerian hormone type-2 receptor isoform 1 (human)

hAMHR2/iso:1


"An anti-Muellerian hormone type-2 receptor isoform 1 that is encoded in the genome of human." [PMID:10589763, PRO:CNA]

Yes

organism-sequence



PR:Q8K592-1

anti-Muellerian hormone type-2 receptor isoform 1 (mouse)

mAMHR2/iso:1


"An anti-Muellerian hormone type-2 receptor isoform 1 that is encoded in the genome of mouse." [PMID:23624077, PMID:9299437, PRO:HJD]

Yes

sequence



PR:000037250

anti-Muellerian hormone type-2 receptor isoform Delta2

AMHR2/iso:Delta2


"An anti-Muellerian hormone type-2 receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:R4JKA2 or a 1:1 ortholog thereof." [PMID:23624077, PMID:7493017, PMID:8940028, PRO:CNA]


organism-sequence



PR:R4JKA2

anti-Muellerian hormone type-2 receptor isoform Delta2 (mouse)

mAMHR2/iso:Delta2


"An anti-Muellerian hormone type-2 receptor isoform Delta2 that is encoded in the genome of mouse. This sequence lacks the region encoded by exon 2 which is part of the extracellular domain and it is essential for ligand binding." [EMBL:KC920727, PMID:23624077, PRO:HJD]

Yes

sequence



PR:000037252

anti-Muellerian hormone type-2 receptor isoform Delta9/10

AMHR2/iso:Delta9/10


"An anti-Muellerian hormone type-2 receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16671-3 or a 1:1 ortholog thereof." [PMID:23624077, PRO:CNA]


organism-sequence



PR:Q16671-3

anti-Muellerian hormone type-2 receptor isoform Delta9/10 (human)

hAMHR2/iso:Delta9/10


"An anti-Muellerian hormone type-2 receptor isoform Delta9/10 that is encoded in the genome of human. This sequence lacks the region encoded by exons 9 and 10, which is part of the protein kinase domain." [PRO:CNA, UniProtKB:Q16671-3]


organism-sequence



PR:R4JNM3

anti-Muellerian hormone type-2 receptor isoform Delta9/10 (mouse)

mAMHR2/iso:Delta9/10


"An anti-Muellerian hormone type-2 receptor isoform Delta9/10 that is encoded in the genome of mouse. This sequence lacks the region encoded by exons 9 and 10, which is part of the protein kinase domain." [EMBL:KC920726, PMID:23624077, PRO:HJD]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000009 AMHR2 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PIRSF:PIRSF037392
GO:0007548 sex differentiation PIRSF:PIRSF037392
PR:000000075 hAMHR2/var:R54C
Example: UniProtKB:Q16671-1, Arg-54, CHEBI:29950
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8872466
PR:000000076 hAMHR2/var:G142V
Example: UniProtKB:Q16671-1, Gly-142, CHEBI:30015
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8872466
PR:000000077 hAMHR2/var:H282Q
Example: UniProtKB:Q16671-1, His-282, CHEBI:30011
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8872466
PR:000000078 hAMHR2/var:R406Q
Example: UniProtKB:Q16671-1, Arg-406, CHEBI:30011
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:11549681
PR:000000079 hAMHR2/var:D426G
Example: UniProtKB:Q16671-1, Asp-426, CHEBI:29947
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8872466
PR:000000080 hAMHR2/var:V458A
Example: UniProtKB:Q16671-1, Val-458, CHEBI:46217
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8872466
PR:000000081 hAMHR2/var:D491H
Example: UniProtKB:Q16671-1, Asp-491, CHEBI:29979
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8872466
PR:000000082 hAMHR2/var:R504C
Example: UniProtKB:Q16671-1, Arg-504, CHEBI:29950
associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8872466
PR:Q16671-1 hAMHR2/iso:1 acts_upstream_of_or_withinGO:0001880 Mullerian duct regression PMID:14750901
GO:0007165 signal transduction PMID:7493017
GO:0007548 sex differentiation PMID:12834017
enablesGO:0038023 signaling receptor activity PMID:7493017
GO:0042562 hormone binding PMID:14750901; PMID:7493017
PR:Q8K592-1 mAMHR2/iso:1 acts_upstream_of_or_withinGO:0007548 sex differentiation PMID:8895659
GO:1990262 anti-Mullerian hormone receptor signaling pathway MGI_ref:5499265; PMID:23624077
enablesGO:1990272 anti-Mullerian hormone receptor activity MGI_ref:5499265; PMID:23624077
PR:R4JKA2 mAMHR2/iso:Delta2
This sequence lacks the region encoded by exon 2 which is part of the extracellular domain and it is essential for ligand binding
acts_upstream_of_or_withinGO:1902613 negative regulation of anti-Mullerian hormone signaling pathway MGI_ref:5499265; PMID:23624077
PR:R4JNM3 mAMHR2/iso:Delta9/10
This sequence lacks the region encoded by exons 9 and 10, which is part of the protein kinase domain
acts_upstream_of_or_withinGO:1902613 negative regulation of anti-Mullerian hormone signaling pathway MGI_ref:5499265; PMID:23624077