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Protein Ontology report - TGF-beta superfamily receptor type-1
PR:000000006 - http://purl.obolibrary.org/obo/PR_000000006
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000006   
  PRO nameTGF-beta superfamily receptor type-1 
  Synonyms
Other: TbetaR-I (BROAD) | TGF-beta receptor type I (BROAD) | TGF-beta type I receptor (BROAD) | TGFR-1 (BROAD) | transforming growth factor-beta receptor type I (BROAD)
  Definition"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an extracellular Activin types I and II receptor domain (Pfam:PF01064), a transmembrane domain, a Transforming growth factor beta type I GS-motif (Pfam:PF08515) and a Protein kinase domain (Pfam:PF00069). The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type-1, and type-2 receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The type 1 receptors are characterized by the presence of a glycine-serine rich juxta-membrane domain (the GS-motif) that is critical for their activation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 24                                        
         Sequence12                                                  Organism-Sequence 93                                        
         Modification19                                                  Organism-Modification 36                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF037391
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000006
TGF-beta superfamily receptor type-1
TGFBR2
"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an extracellular Activin types I and II receptor domain (Pfam:PF01064), a transmembrane domain, a Transforming growth factor beta type I GS-motif (Pfam:PF08515) and a Protein kinase domain (Pfam:PF00069). The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type-1, and type-2 receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The type 1 receptors are characterized by the presence of a glycine-serine rich juxta-membrane domain (the GS-motif) that is critical for their activation." [PRO:CNA]
Yes
gene


PR:000000035
BMP receptor type-1A
BMPR1A
"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1A gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2 and BMP4." [PRO:CNA]

organism-gene


PR:P36894
bone morphogenetic protein receptor type-1A (human)
hBMPR1A
"A BMP receptor type-1A that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36894]

organism-sequence


PR:000000137
BMP receptor type-1A sequence variant Y62D (human)
hBMPR1A/var:Y62D
"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Tyr-62 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Tyr-62, CHEBI:29958." [PMID:12417513, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000138
BMP receptor type-1A sequence variant C82Y (human)
hBMPR1A/var:C82Y
"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-82 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-82, CHEBI:46858." [PMID:12417513, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000139
BMP receptor type-1A sequence variant C124R (human)
hBMPR1A/var:C124R
"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-124 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-124, CHEBI:29952." [PMID:11536076, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000140
BMP receptor type-1A sequence variant C130R (human)
hBMPR1A/var:C130R
"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-130 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-130, CHEBI:29952." [PMID:12136244, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000141
BMP receptor type-1A sequence variant A338D (human)
hBMPR1A/var:A338D
"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Ala-338 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Ala-338, CHEBI:29958." [PMID:11536076, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000142
BMP receptor type-1A sequence variant C376Y (human)
hBMPR1A/var:C376Y
"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-376 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-376, CHEBI:46858." [PMID:11536076, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000143
BMP receptor type-1A sequence variant R443C (human)
hBMPR1A/var:R443C
"A bone morphogenetic protein receptor type-1A (human) that has a Cys residue at the position equivalent to Arg-443 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Arg-443, CHEBI:29950." [PMID:12417513, PMID:17344846, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000144
BMP receptor type-1A sequence variant M470T (human)
hBMPR1A/var:M470T
"A bone morphogenetic protein receptor type-1A (human) that has a Thr residue at the position equivalent to Met-470 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Met-470, CHEBI:30013." [PMID:12630959, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:P36894-1
bone morphogenetic protein receptor type-1A isoform 1 (human)
hBMPR1A/iso:1
"A BMP receptor type-1A isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036422
BMP receptor type-1A isoform 1 phosphorylated 1 (human)
hBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]
Yes
organism-modification


PR:000036424
BMP receptor type-1A isoform 1 phosphorylated 2 (human)
hBMPR1A/iso:1/Phos:2
"A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]

organism-modification


PR:000046493
bone morphogenetic protein receptor type-1A, signal peptide removed form (human)
hBMPR1A/SigPep-
"A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed. UniProtKB:P36894, 24-532." [PRO:DNx, Reactome:R-HSA-201480]

organism-modification


PR:000046494
bone morphogenetic protein receptor type-1A, signal peptide removed phosphorylated 2 (human)
hBMPR1A/SigPep-/Phos:2
"A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 215, 216, 218 and 220 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, 24-532, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PRO:DNx, Reactome:R-HSA-201448]

organism-gene


PR:P36895
bone morphogenetic protein receptor type-1A (mouse)
mBMPR1A
"A BMP receptor type-1A that is encoded in the genome of mouse." [OMA:P36895, PRO:DNx]

organism-sequence


PR:P36895-1
bone morphogenetic protein receptor type-1A isoform 1 (mouse)
mBMPR1A/iso:1
"A BMP receptor type-1A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036423
BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)
mBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in mouse." [PMID:10814522, PMID:9738003, PRO:CNA]
Yes
organism-gene


PR:Q78EA7
bone morphogenetic protein receptor type-1A (rat)
rBMPR1A
"A BMP receptor type-1A that is encoded in the genome of rat." [OMA:Q78EA7, PRO:DNx]

sequence


PR:000000136
BMP receptor type-1A isoform 1
BMPR1A/iso:1
"A BMP receptor type-1A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36894-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P36894-1
bone morphogenetic protein receptor type-1A isoform 1 (human)
hBMPR1A/iso:1
"A BMP receptor type-1A isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036422
BMP receptor type-1A isoform 1 phosphorylated 1 (human)
hBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]
Yes
organism-modification


PR:000036424
BMP receptor type-1A isoform 1 phosphorylated 2 (human)
hBMPR1A/iso:1/Phos:2
"A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]

organism-sequence


PR:P36895-1
bone morphogenetic protein receptor type-1A isoform 1 (mouse)
mBMPR1A/iso:1
"A BMP receptor type-1A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036423
BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)
mBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in mouse." [PMID:10814522, PMID:9738003, PRO:CNA]
Yes
modification


PR:000000382
BMP receptor type-1A isoform 1 phosphorylated form
BMPR1A/iso:1/PhosRes+
"A BMP receptor type-1A isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000498
BMP receptor type-1A isoform 1 phosphorylated 1
BMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated form in which the phosphorylation occurs within the GS-motif by BMP receptor type-2 upon BMP ligand binding." [PMID:12829744, PRO:CNA]

organism-modification


PR:000036422
BMP receptor type-1A isoform 1 phosphorylated 1 (human)
hBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]
Yes
organism-modification


PR:000036423
BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)
mBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in mouse." [PMID:10814522, PMID:9738003, PRO:CNA]
Yes
modification


PR:000000499
BMP receptor type-1A isoform 1 phosphorylated 2
BMPR1A/iso:1/Phos:2
"A BMP receptor type-1A isoform 1 phosphorylated form in which the phosphorylation occurs upon EGF induction. Example: UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA, PRO:DAN]

organism-modification


PR:000036424
BMP receptor type-1A isoform 1 phosphorylated 2 (human)
hBMPR1A/iso:1/Phos:2
"A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]

gene


PR:000000036
BMP receptor type-1B
BMPR1B
"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1B gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1." [PRO:CNA]

organism-gene


PR:O00238
bone morphogenetic protein receptor type-1B (human)
hBMPR1B
"A BMP receptor type-1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00238]

organism-sequence


PR:000000146
BMP receptor type-1B sequence variant I200K (human)
hBMPR1B/var:I200K
"A bone morphogenetic protein receptor type-1B (human) that has a Lys residue at the position equivalent to Ile-200 of the amino acid sequence represented by UniProtKB:O00238-1. Example: UniProtKB:O00238-1, Ile-200, CHEBI:29967." [PMID:14523231, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000147
BMP receptor type-1B sequence variant R486W (human)
hBMPR1B/var:R486W
"A bone morphogenetic protein receptor type-1B (human) that has a Trp residue at the position equivalent to Arg-486 of the amino acid sequence represented by UniProtKB:O00238-1. Example: UniProtKB:O00238-1, Arg-486, CHEBI:29954." [PMID:14523231, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:O00238-1
bone morphogenetic protein receptor type-1B isoform 1 (human)
hBMPR1B/iso:1
"A BMP receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036426
BMP receptor type-1B isoform 1 phosphorylated 1 (human)
hBMPR1B/iso:1/Phos:1
"A BMP receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:10051328, PMID:14523231, PRO:CNA]
Yes
organism-sequence


PR:O00238-2
bone morphogenetic protein receptor type-1B isoform h2 (human)
hBMPR1B/iso:h2
"A bone morphogenetic protein receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00238-2." [PRO:DNx, UniProtKB:O00238]

organism-modification


PR:000046495
bone morphogenetic protein receptor type-1B, signal peptide removed form (human)
hBMPR1B/SigPep-
"A bone morphogenetic protein receptor type-1B (human) that has had the signal peptide removed. UniProtKB:O00238, 14-502." [PRO:DNx, Reactome:R-HSA-201657]

organism-modification


PR:000046496
bone morphogenetic protein receptor type-1B, signal peptide removed phosphoserine(4+) form (human)
hBMPR1B/SigPep-/PhosSer(4+)
"A bone morphogenetic protein receptor type-1B (human) that has had the signal peptide removed and that includes at least four phosphorylated serines. UniProtKB:O00238, 14-502, MOD:00046(4+)." [PRO:DNx, Reactome:R-HSA-201814]

organism-gene


PR:P36898
bone morphogenetic protein receptor type-1B (mouse)
mBMPR1B
"A BMP receptor type-1B that is encoded in the genome of mouse." [OMA:P36898, PRO:DNx]

organism-sequence


PR:P36898-1
bone morphogenetic protein receptor type-1B isoform 1 (mouse)
mBMPR1B/iso:1
"A BMP receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036425
BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)
mBMPR1B/iso:1/Phos:1
"A BMP receptor type-1B isoform 1 phosphorylated 1 in mouse." [PMID:10631181, PMID:10712517, PMID:14523231, PRO:CNA]
Yes
organism-gene


PR:Q05438
bone morphogenetic protein receptor type-1B (chicken)
chick-BMPR1B
"A BMP receptor type-1B that is encoded in the genome of chicken." [OMA:Q05438, PRO:DNx]

organism-gene


PR:Q09488
serine/threonine-protein kinase receptor sma-6 (worm)
BMPR1B (worm)
"A BMP receptor type-1B that is encoded in the genome of worm." [OMA:Q09488, PRO:DNx]

organism-gene


PR:Q569A5
receptor protein serine/threonine kinase (rat)
rBMPR1B
"A BMP receptor type-1B that is encoded in the genome of rat." [PANTHER:PTHR23255:SF35, PRO:DNx]

sequence


PR:000000145
BMP receptor type-1B isoform 1
BMPR1B/iso:1
"A BMP receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00238-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:O00238-1
bone morphogenetic protein receptor type-1B isoform 1 (human)
hBMPR1B/iso:1
"A BMP receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036426
BMP receptor type-1B isoform 1 phosphorylated 1 (human)
hBMPR1B/iso:1/Phos:1
"A BMP receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:10051328, PMID:14523231, PRO:CNA]
Yes
organism-sequence


PR:P36898-1
bone morphogenetic protein receptor type-1B isoform 1 (mouse)
mBMPR1B/iso:1
"A BMP receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036425
BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)
mBMPR1B/iso:1/Phos:1
"A BMP receptor type-1B isoform 1 phosphorylated 1 in mouse." [PMID:10631181, PMID:10712517, PMID:14523231, PRO:CNA]
Yes
modification


PR:000000383
BMP receptor type-1B isoform 1 phosphorylated form
BMPR1B/iso:1/PhosRes+
"A BMP receptor type-1B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000500
BMP receptor type-1B isoform 1 phosphorylated 1
BMPR1B/iso:1/Phos:1
"A BMP receptor type-1B isoform 1 phosphorylated form in which the phosphorylation occurs within the GS-motif by the BMP receptor type-2 upon BMP ligand binding." [PRO:CNA]

organism-modification


PR:000036425
BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)
mBMPR1B/iso:1/Phos:1
"A BMP receptor type-1B isoform 1 phosphorylated 1 in mouse." [PMID:10631181, PMID:10712517, PMID:14523231, PRO:CNA]
Yes
organism-modification


PR:000036426
BMP receptor type-1B isoform 1 phosphorylated 1 (human)
hBMPR1B/iso:1/Phos:1
"A BMP receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:10051328, PMID:14523231, PRO:CNA]
Yes
gene


PR:000000047
TGF-beta receptor type-1
TGFBR1
"A TGF-beta superfamily receptor type-1 that is a translation product of the human TGFBR1 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P36897
TGF-beta receptor type-1 (human)
hTGFBR1
"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897]

organism-sequence


PR:000000186
TGF-beta receptor type-1 sequence variant T200I (human)
hTGFBR1/var:T200I
"A TGF-beta receptor type-1 (human) that has an Ile residue at the position equivalent to Thr-200 of the amino acid sequence represented by UniProtKB:P36897. UniProtKB:P36897, Thr-200, CHEBI:30009." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000187
TGF-beta receptor type-1 sequence variant 10 (human)
hTGFBR1/var:10
"A TGF-beta receptor type-1 (human) that has an insertion of an Ala residue at the position equivalent to Ala-26 of the amino acid sequence represented by UniProtKB:P36897." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000188
TGF-beta receptor type-1 sequence variant 11 (human)
hTGFBR1/var:11
"A TGF-beta receptor type-1 (human) that has a three-residue deletion at the position equivalent to region 24-26 of the amino acid sequence represented by UniProtKB:P36897-1. UniProtKB:P36897, 1-23, 27-503." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000189
TGF-beta receptor type-1 sequence variant K232E (human)
hTGFBR1/var:K232E
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Lys-232 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972." [PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000190
TGF-beta receptor type-1 sequence variant S241L (human)
hTGFBR1/var:S241L
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006." [PMID:16596670, PMID:16791849, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000191
TGF-beta receptor type-1 sequence variant N267H (human)
hTGFBR1/var:N267H
"A TGF-beta receptor type-1 (human) that has a His residue at the position equivalent to Asn-267 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979." [PMID:16791849, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000192
TGF-beta receptor type-1 sequence variant M318R (human)
hTGFBR1/var:M318R
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Met-318 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Met-318, CHEBI:29952." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000193
TGF-beta receptor type-1 sequence variant D400G (human)
hTGFBR1/var:D400G
"A TGF-beta receptor type-1 (human) that has a Gly residue at the position equivalent to Asp-400 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000194
TGF-beta receptor type-1 sequence variant R487P (human)
hTGFBR1/var:R487P
"A TGF-beta receptor type-1 (human) that has a Pro residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342." [PMID:15731757, PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000195
TGF-beta receptor type-1 sequence variant R487E (human)
hTGFBR1/var:R487E
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972." [PMID:16791849, PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000196
TGF-beta receptor type-1 sequence variant R487W (human)
hTGFBR1/var:R487W
"A TGF-beta receptor type-1 (human) that has a Trp residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954." [PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:P36897-1
TGF-beta receptor type-1 isoform 1 (human)
hTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-sequence


PR:P36897-2
TGF-beta receptor type-1 isoform h2 (human)
hTGFBR1/iso:h2
"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-2." [PRO:DNx, UniProtKB:P36897]

organism-sequence


PR:P36897-3
TGF-beta receptor type-1 isoform h3 (human)
hTGFBR1/iso:h3
"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-3." [PRO:DNx, UniProtKB:P36897]

organism-modification


PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]

organism-modification


PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification


PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]

organism-modification


PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]

organism-modification


PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]

organism-modification


PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]

organism-modification


PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]

organism-modification


PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-
"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]

organism-modification


PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]

organism-modification


PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]

organism-modification


PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]

organism-modification


PR:000067321
TGF-beta receptor type-1 methylated 1 (human)
hTGFBR1/Me:1
"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-474 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-474, MOD:00660." [IEDB_epitope:1046772, PRO:DNx]

organism-modification


PR:000070298
TGF-beta receptor type-1 methylated 2 (human)
hTGFBR1/Me:2
"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-461 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-461, MOD:00660." [IEDB_epitope:1039294, PRO:DNx]

organism-modification


PR:000075184
TGF-beta receptor type-1 cysteinylated 1 (human)
hTGFBR1/Cyst:1
"A TGF-beta receptor type-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-71 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-71, MOD:00765." [IEDB_epitope:2129187, IEDB_epitope:2129188, PRO:DNx]

organism-gene


PR:P80204
TGF-beta receptor type-1 (rat)
rTGFBR1
"A TGF-beta receptor type-1 that is encoded in the genome of rat." [OMA:P80204, PRO:DNx]

organism-gene


PR:Q64729
TGF-beta receptor type-1 (mouse)
mTGFBR1
"A TGF-beta receptor type-1 that is encoded in the genome of mouse." [OMA:Q64729, PRO:DNx]

organism-sequence


PR:Q64729-1
TGF-beta receptor type-1 isoform 1 (mouse)
mTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
organism-sequence


PR:Q64729-2
TGF-beta receptor type-1 isoform m2 (mouse)
mTGFBR1/iso:m2
"A TGF-beta receptor type-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64729-2." [PRO:DNx, UniProtKB:Q64729]

sequence


PR:000000185
TGF-beta receptor type-1 isoform 1
TGFBR1/iso:1
"A TGF-beta receptor type-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P36897-1
TGF-beta receptor type-1 isoform 1 (human)
hTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-sequence


PR:Q64729-1
TGF-beta receptor type-1 isoform 1 (mouse)
mTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
modification


PR:000000522
TGF-beta receptor type-1 isoform 1, signal peptide removed form
TGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]

modification


PR:000000408
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form
TGFBR1/iso:1/SigPep-/PhosRes+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000523
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
TGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification


PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
modification


PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]

modification


PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]

organism-modification


PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
modification


PR:000025411
TGF-beta receptor type-1 proteolytic cleavage product
TGFBR1/ClvPrd
"A TGF-beta receptor type-1 that has been processed by proteolytic cleavage." [PRO:DNx]

modification


PR:000025932
TGF-beta receptor type-1, signal peptide removed form
TGFBR1/SigPep-
"A TGF-beta receptor type-1 that has had the signal peptide removed." [PRO:CNA]

modification


PR:000000522
TGF-beta receptor type-1 isoform 1, signal peptide removed form
TGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]

modification


PR:000000408
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form
TGFBR1/iso:1/SigPep-/PhosRes+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000523
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
TGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification


PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
modification


PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]

modification


PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]

organism-modification


PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification


PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]

organism-modification


PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification


PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]

organism-modification


PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]

organism-modification


PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]

organism-modification


PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]

organism-modification


PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]

organism-modification


PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-
"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]

organism-modification


PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]

organism-modification


PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]

gene


PR:000000067
activin receptor type-1
ACVR1
"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P37172
activin receptor type-1 (mouse)
mACVR1
"An activin receptor type-1 that is encoded in the genome of mouse." [OMA:P37172, PRO:DNx]

organism-sequence


PR:P37172-1
activin receptor type-1 isoform 1 (mouse)
mACVR1/iso:1
"An activin receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036436
activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mACVR1/iso:1/SigPep-/Phos:1
"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse." [PMID:11376112, PRO:CNA]
Yes
organism-gene


PR:P80201
activin receptor type-1 (rat)
rACVR1
"An activin receptor type-1 that is encoded in the genome of rat." [OMA:P80201, PRO:DNx]

organism-gene


PR:Q04771
activin receptor type-1 (human)
hACVR1
"An activin receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q04771]

organism-sequence


PR:000000200
activin receptor type-1 sequence variant R206H (human)
hACVR1/var:R206H
"An activin receptor type-1 (human) that has a His residue at the position equivalent to Arg-206 of the amino acid sequence represented by UniProtKB:Q04771. This variation is located within the GS-motif. UniProtKB:Q04771, Arg-206, CHEBI:29979." [PMID:8397373, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:Q04771-1
activin receptor type-1 isoform 1 (human)
hACVR1/iso:1
"An activin receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036435
activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hACVR1/iso:1/SigPep-/Phos:1
"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human." [PMID:8242742, PMID:8389764, PMID:8397373, PRO:CNA]
Yes
organism-modification


PR:000068633
activin receptor type-1 cysteinylated 1 (human)
hACVR1/Cyst:1
"An activin receptor type-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-35 of the amino acid sequence represented by UniProtKB:Q04771. UniProtKB:Q04771, Cys-35, MOD:00765." [IEDB_epitope:2118215, PRO:DNx]

organism-gene


PR:Q90ZK6
activin receptor type-1 (chicken)
chick-ACVR1
"An activin receptor type-1 that is encoded in the genome of chicken." [OMA:Q90ZK6, PRO:DNx]

sequence


PR:000000199
activin receptor type-1 isoform 1
ACVR1/iso:1
"An activin receptor type-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04771-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P37172-1
activin receptor type-1 isoform 1 (mouse)
mACVR1/iso:1
"An activin receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036436
activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mACVR1/iso:1/SigPep-/Phos:1
"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse." [PMID:11376112, PRO:CNA]
Yes
organism-sequence


PR:Q04771-1
activin receptor type-1 isoform 1 (human)
hACVR1/iso:1
"An activin receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036435
activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hACVR1/iso:1/SigPep-/Phos:1
"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human." [PMID:8242742, PMID:8389764, PMID:8397373, PRO:CNA]
Yes
modification


PR:000021938
activin receptor type-1 isoform 1, signal peptide removed form
ACVR1/iso:1/SigPep-
"An activin receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:DAN]

modification


PR:000000411
activin receptor type-1 isoform 1, signal peptide removed phosphorylated form
ACVR1/iso:1/SigPep-/PhosRes+
"An activin receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000524
activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1
ACVR1/iso:1/SigPep-/Phos:1
"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs at Ser/Thr residues within the GS-motif region (GSGSGLP and surrounding sequence) by the activated activin receptor type-2 (PR:000000528 or PR:000000529)." [PRO:CNA]

organism-modification


PR:000036435
activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hACVR1/iso:1/SigPep-/Phos:1
"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human." [PMID:8242742, PMID:8389764, PMID:8397373, PRO:CNA]
Yes
organism-modification


PR:000036436
activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mACVR1/iso:1/SigPep-/Phos:1
"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse." [PMID:11376112, PRO:CNA]
Yes
gene


PR:000000068
activin receptor type-1B
ACVR1B
"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1B gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P36896
activin receptor type-1B (human)
hACVR1B
"An activin receptor type-1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36896]

organism-sequence


PR:P36896-1
activin receptor type-1B isoform 1 (human)
hACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036437
activin receptor type-1B isoform 1 phosphorylated 1 (human)
hACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]
Yes
organism-modification


PR:000036438
activin receptor type-1B isoform 1 phosphorylated 2 (human)
hACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]

organism-sequence


PR:P36896-2
activin receptor type-1B isoform 2 (human)
hACVR1B/iso:2
"An activin receptor type-1B isoform 2 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-sequence


PR:P36896-3
activin receptor type-1B isoform 3 (human)
hACVR1B/iso:3
"An activin receptor type-1B isoform 3 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-sequence


PR:P36896-4
activin receptor type-1B isoform h4 (human)
hACVR1B/iso:h4
"An activin receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-4." [PRO:DNx, UniProtKB:P36896]

organism-sequence


PR:P36896-5
activin receptor type-1B isoform h5 (human)
hACVR1B/iso:h5
"An activin receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-5." [PRO:DNx, UniProtKB:P36896]

organism-modification


PR:000046256
activin receptor type-1B, signal peptide removed form (human)
hACVR1B/SigPep-
"An activin receptor type-1B (human) that has had the signal peptide removed. UniProtKB:P36896, 24-505." [PRO:DNx, Reactome:R-HSA-205867]

organism-modification


PR:000046257
activin receptor type-1B, signal peptide removed phosphorylated 3 (human)
hACVR1B/SigPep-/Phos:3
"An activin receptor type-1B (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 187, 189, 191 and 193, and phosphothreonine at positions 188 and 206 of the amino acid sequence represented by UniProtKB:P36896. UniProtKB:P36896, 24-505, Ser-187/Ser-189/Ser-191/Ser-193, MOD:00046|Thr-188/Thr-206, MOD:00047." [PRO:DNx, Reactome:R-HSA-205780]

organism-gene


PR:P80202
activin receptor type-1B (rat)
rACVR1B
"An activin receptor type-1B that is encoded in the genome of rat." [OMA:P80202, PRO:DNx]

organism-gene


PR:Q61271
activin receptor type-1B (mouse)
mACVR1B
"An activin receptor type-1B that is encoded in the genome of mouse." [OMA:Q61271, PRO:DNx]

organism-sequence


PR:Q61271-1
activin receptor type-1B isoform 1 (mouse)
mACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

sequence


PR:000000201
activin receptor type-1B isoform 1
ACVR1B/iso:1
"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P36896-1
activin receptor type-1B isoform 1 (human)
hACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036437
activin receptor type-1B isoform 1 phosphorylated 1 (human)
hACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]
Yes
organism-modification


PR:000036438
activin receptor type-1B isoform 1 phosphorylated 2 (human)
hACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]

organism-sequence


PR:Q61271-1
activin receptor type-1B isoform 1 (mouse)
mACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000000412
activin receptor type-1B isoform 1 phosphorylated form
ACVR1B/iso:1/PhosRes+
"An activin receptor type-1B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000525
activin receptor type-1B isoform 1 phosphorylated 1
ACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated form that is phosphorylated at Ser/Thr residues in the GS-motif region (GSGSGLP and surrounding sequence) by activated activin receptor type-2, and constitutes an active receptor subunit." [PMID:8622651, PMID:8721982, PRO:CNA]

organism-modification


PR:000036437
activin receptor type-1B isoform 1 phosphorylated 1 (human)
hACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]
Yes
modification


PR:000000526
activin receptor type-1B isoform 1 phosphorylated 2
ACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated form that is phosphorylated on a Tyr residue within the protein kinase domain, as a result of platelet activation. Example: UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA, PRO:DAN]

organism-modification


PR:000036438
activin receptor type-1B isoform 1 phosphorylated 2 (human)
hACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]

sequence


PR:000000202
activin receptor type-1B isoform 2
ACVR1B/iso:2
"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-2 or a 1:1 ortholog thereof." [PMID:11117535, PRO:CNA, PRO:DAN]

organism-sequence


PR:P36896-2
activin receptor type-1B isoform 2 (human)
hACVR1B/iso:2
"An activin receptor type-1B isoform 2 that is encoded in the genome of human." [PRO:CNA]
Yes
sequence


PR:000000203
activin receptor type-1B isoform 3
ACVR1B/iso:3
"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-3 or a 1:1 ortholog thereof." [PMID:11117535, PRO:CNA, PRO:DAN]

organism-sequence


PR:P36896-3
activin receptor type-1B isoform 3 (human)
hACVR1B/iso:3
"An activin receptor type-1B isoform 3 that is encoded in the genome of human." [PRO:CNA]
Yes
gene


PR:000000069
activin receptor type-1C
ACVR1C
"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1C gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P70539
activin receptor type-1C (rat)
rACVR1C
"An activin receptor type-1C that is encoded in the genome of rat." [OMA:P70539, PRO:DNx]

organism-gene


PR:Q8K348
activin receptor type-1C (mouse)
mACVR1C
"An activin receptor type-1C that is encoded in the genome of mouse." [OMA:Q8K348, PRO:DNx]

organism-sequence


PR:A2AJR5
activin receptor type-1C isoform 3 (mouse)
mACVR1C/iso:3
"An activin receptor type-1C isoform 3 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]

organism-sequence


PR:A2AJR6
activin receptor type-1C isoform 2 (mouse)
mACVR1C/iso:2
"An activin receptor type-1C isoform 2 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q8K348-1
activin receptor type-1C isoform 1 (mouse)
mACVR1C/iso:1
"An activin receptor type-1C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-gene


PR:Q8NER5
activin receptor type-1C (human)
hACVR1C
"An activin receptor type-1C that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8NER5]

organism-sequence


PR:Q8NER5-1
activin receptor type-1C isoform 1 (human)
hACVR1C/iso:1
"An activin receptor type-1C isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036439
activin receptor type-1C isoform 1 phosphorylated 1 (human)
hACVR1C/iso:1/Phos:1
"An activin receptor type-1C isoform 1 phosphorylated 1 in human." [PMID:12063393, PMID:12065756, PMID:12606401, PMID:15196700, PMID:15531507, PRO:CNA]
Yes
organism-sequence


PR:Q8NER5-2
activin receptor type-1C isoform 2 (human)
hACVR1C/iso:2
"An activin receptor type-1C isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:Q8NER5-3
activin receptor type-1C isoform 3 (human)
hACVR1C/iso:3
"An activin receptor type-1C isoform 3 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:Q8NER5-4
activin receptor type-1C isoform 4 (human)
hACVR1C/iso:4
"An activin receptor type-1C isoform 4 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000060490
activin receptor type-1C, signal peptide removed form (human)
hACVR1C/SigPep-
"An activin receptor type-1C (human) that has had the signal peptide removed. Example: UniProtKB:Q8NER5-1, 21-493." [PRO:DNx, Reactome:R-HSA-1181117]

organism-modification


PR:000063700
activin receptor type-1C, signal peptide removed phosphorylated 1 (human)
hACVR1C/SigPep-/Phos:1
"An activin receptor type-1C (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Thr-175, Ser-177, Ser-179, Ser-181, and Thr-194 of the amino acid sequence represented by UniProtKB:Q8NER5-1. Example: UniProtKB:Q8NER5-1, 21-493, Thr-175/Thr-194, MOD:00047|Ser-177/Ser-179/Ser-181, MOD:00046." [PRO:DNx, Reactome:R-HSA-1181110]

sequence


PR:000000204
activin receptor type-1C isoform 1
ACVR1C/iso:1
"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q8K348-1
activin receptor type-1C isoform 1 (mouse)
mACVR1C/iso:1
"An activin receptor type-1C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-sequence


PR:Q8NER5-1
activin receptor type-1C isoform 1 (human)
hACVR1C/iso:1
"An activin receptor type-1C isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036439
activin receptor type-1C isoform 1 phosphorylated 1 (human)
hACVR1C/iso:1/Phos:1
"An activin receptor type-1C isoform 1 phosphorylated 1 in human." [PMID:12063393, PMID:12065756, PMID:12606401, PMID:15196700, PMID:15531507, PRO:CNA]
Yes
modification


PR:000000413
activin receptor type-1C isoform 1 phosphorylated form
ACVR1C/iso:1/PhosRes+
"An activin receptor type-1C isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000527
activin receptor type-1C isoform 1 phosphorylated 1
ACVR1C/iso:1/Phos:1
"An activin receptor type-1C isoform 1 phosphorylated form that is phosphorylated at Ser/Thr residues in the GS-motif by activated activin receptor type-2, and constitutes an active receptor subunit." [PMID:15196700]

organism-modification


PR:000036439
activin receptor type-1C isoform 1 phosphorylated 1 (human)
hACVR1C/iso:1/Phos:1
"An activin receptor type-1C isoform 1 phosphorylated 1 in human." [PMID:12063393, PMID:12065756, PMID:12606401, PMID:15196700, PMID:15531507, PRO:CNA]
Yes
sequence


PR:000000205
activin receptor type-1C isoform 2
ACVR1C/iso:2
"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-2 or a 1:1 ortholog thereof." [PMID:12606401, PRO:CNA, PRO:DAN]

organism-sequence


PR:A2AJR6
activin receptor type-1C isoform 2 (mouse)
mACVR1C/iso:2
"An activin receptor type-1C isoform 2 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q8NER5-2
activin receptor type-1C isoform 2 (human)
hACVR1C/iso:2
"An activin receptor type-1C isoform 2 that is encoded in the genome of human." [PRO:CNA]

sequence


PR:000000206
activin receptor type-1C isoform 3
ACVR1C/iso:3
"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-3 or a 1:1 ortholog thereof." [PMID:12606401, PRO:CNA, PRO:DAN]

organism-sequence


PR:A2AJR5
activin receptor type-1C isoform 3 (mouse)
mACVR1C/iso:3
"An activin receptor type-1C isoform 3 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q8NER5-3
activin receptor type-1C isoform 3 (human)
hACVR1C/iso:3
"An activin receptor type-1C isoform 3 that is encoded in the genome of human." [PRO:CNA]

sequence


PR:000000207
activin receptor type-1C isoform 4
ACVR1C/iso:4
"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-4 or a 1:1 ortholog thereof." [PMID:12606401, PRO:CNA, PRO:DAN]

organism-sequence


PR:Q8NER5-4
activin receptor type-1C isoform 4 (human)
hACVR1C/iso:4
"An activin receptor type-1C isoform 4 that is encoded in the genome of human." [PRO:CNA]
Yes
gene


PR:000000126
activin receptor type-1-like
ACVRL1
"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVRL1 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P37023
activin receptor type-1-like (human)
hACVRL1
"An activin receptor type-1-like that is encoded in the genome of human." [PRO:CNA, UniProtKB:P37023]

organism-sequence


PR:000000317
activin receptor type-1-like sequence variant G48R (human)
hACVRL1/var:G48R
"An activin receptor type-1-like (human) that has an Arg residue at the position equivalent to Gly-48 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Gly-48, CHEBI:29952." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000318
activin receptor type-1-like sequence variant E215K (human)
hACVRL1/var:E215K
"An activin receptor type-1-like (human) that has a Lys residue at the position equivalent to Glu-215 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Glu-215, CHEBI:29967." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000319
activin receptor type-1-like sequence variant H222del (human)
hACVRL1/var:H222del
"An activin receptor type-1-like (human) that has a single-residue deletion at the position equivalent to His-222 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, 22-221, 223-503." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000320
activin receptor type-1-like sequence variant S233del (human)
hACVRL1/var:S233del
"An activin receptor type-1-like (human) that has a single-residue deletion at the position equivalent to Ser-233 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, 22-232, 234-503." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000321
activin receptor type-1-like sequence variant G223R (human)
hACVRL1/var:G223R
"An activin receptor type-1-like (human) that has an Arg residue at the position equivalent to Gly-223 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Gly-223, CHEBI:29952." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000322
activin receptor type-1-like sequence variant K229R (human)
hACVRL1/var:K229R
"An activin receptor type-1-like (human) that has an Arg residue at the position equivalent to Lys-229 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Lys-229, CHEBI:29952." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000323
activin receptor type-1-like sequence variant D254del (human)
hACVRL1/var:D254del
"An activin receptor type-1-like (human) that has a single-residue deletion at the position equivalent to Asp-254 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, 22-253, 255-503." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000324
activin receptor type-1-like sequence variant M376V (human)
hACVRL1/var:M376V
"An activin receptor type-1-like (human) that has a Val residue at the position equivalent to Met-376 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Met-376, CHEBI:30015." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000325
activin receptor type-1-like sequence variant L285F (human)
hACVRL1/var:L285F
"An activin receptor type-1-like (human) that has a Phe residue at the position equivalent to Leu-285 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Leu-285, CHEBI:29997." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000326
activin receptor type-1-like sequence variant A306P (human)
hACVRL1/var:A306P
"An activin receptor type-1-like (human) that has a Pro residue at the position equivalent to Ala-306 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Ala-306, CHEBI:50342." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000327
activin receptor type-1-like sequence variant H314Y (human)
hACVRL1/var:H314Y
"An activin receptor type-1-like (human) that has a Tyr residue at the position equivalent to His-314 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, His-314, CHEBI:46858." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000328
activin receptor type-1-like sequence variant W50C (human)
hACVRL1/var:W50C
"An activin receptor type-1-like (human) that has a Cys residue at the position equivalent to Trp-50 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Trp-50, CHEBI:29950." [PMID:10767348, PMID:14684682, PMID:9245985, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000329
activin receptor type-1-like sequence variant S333I (human)
hACVRL1/var:S333I
"An activin receptor type-1-like (human) that has an Ile residue at the position equivalent to Ser-333 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Ser-333, CHEBI:30009." [PMID:10767348, PMID:14684682, PMID:9245985, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000330
activin receptor type-1-like sequence variant L337P (human)
hACVRL1/var:L337P
"An activin receptor type-1-like (human) that has a Pro residue at the position equivalent to Leu-337 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Leu-337, CHEBI:50342." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000331
activin receptor type-1-like sequence variant C344Y (human)
hACVRL1/var:C344Y
"An activin receptor type-1-like (human) that has a Tyr residue at the position equivalent to Cys-344 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Cys-344, CHEBI:46858." [PMID:10767348, PMID:14684682, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000332
activin receptor type-1-like sequence variant A347P (human)
hACVRL1/var:A347P
"An activin receptor type-1-like (human) that has a Pro residue at the position equivalent to Ala-347 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Ala-347, CHEBI:50342." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000333
activin receptor type-1-like sequence variant R374Q (human)
hACVRL1/var:R374Q
"An activin receptor type-1-like (human) that has a Gln residue at the position equivalent to Arg-374 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-374, CHEBI:30011." [PMID:14684682, PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000334
activin receptor type-1-like sequence variant R374W (human)
hACVRL1/var:R374W
"An activin receptor type-1-like (human) that has a Trp residue at the position equivalent to Arg-374 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-374, CHEBI:29954." [PMID:11170071, PMID:14684682, PMID:15712270, PMID:9245985, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000335
activin receptor type-1-like sequence variant P378L (human)
hACVRL1/var:P378L
"An activin receptor type-1-like (human) that has a Leu residue at the position equivalent to Pro-378 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Pro-378, CHEBI:30006." [PMID:14684682, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000336
activin receptor type-1-like sequence variant E379K (human)
hACVRL1/var:E379K
"An activin receptor type-1-like (human) that has a Lys residue at the position equivalent to Glu-379 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Glu-379, CHEBI:29967." [PMID:15024723, PMID:15712270, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000337
activin receptor type-1-like sequence variant M376R (human)
hACVRL1/var:M376R
"An activin receptor type-1-like (human) that has an Arg residue at the position equivalent to Met-376 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Met-376, CHEBI:29952." [PMID:8640225, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000338
activin receptor type-1-like sequence variant D397G (human)
hACVRL1/var:D397G
"An activin receptor type-1-like (human) that has a Gly residue at the position equivalent to Asp-397 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Asp-397, CHEBI:29947." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000339
activin receptor type-1-like sequence variant C51Y (human)
hACVRL1/var:C51Y
"An activin receptor type-1-like (human) that has a Tyr residue at the position equivalent to Cys-51 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Cys-51, CHEBI:46858." [PMID:11170071, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000340
activin receptor type-1-like sequence variant I398N (human)
hACVRL1/var:I398N
"An activin receptor type-1-like (human) that has an Asn residue at the position equivalent to Ile-398 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Ile-398, CHEBI:50347." [PMID:11170071, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000341
activin receptor type-1-like sequence variant W399S (human)
hACVRL1/var:W399S
"An activin receptor type-1-like (human) that has a Ser residue at the position equivalent to Trp-399 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Trp-399, CHEBI:29999." [PMID:11170071, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000342
activin receptor type-1-like sequence variant E407D (human)
hACVRL1/var:E407D
"An activin receptor type-1-like (human) that has an Asp residue at the position equivalent to Glu-407 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Glu-407, CHEBI:29958." [PMID:10767348, PMID:15712270, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000343
activin receptor type-1-like sequence variant R411P (human)
hACVRL1/var:R411P
"An activin receptor type-1-like (human) that has a Pro residue at the position equivalent to Arg-411 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-411, CHEBI:50342." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000344
activin receptor type-1-like sequence variant R411Q (human)
hACVRL1/var:R411Q
"An activin receptor type-1-like (human) that has a Gln residue at the position equivalent to Arg-411 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-411, CHEBI:30011." [PMID:14684682, PMID:15024723, PMID:8640225, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000345
activin receptor type-1-like sequence variant R411W (human)
hACVRL1/var:R411W
"An activin receptor type-1-like (human) that has a Trp residue at the position equivalent to Arg-411 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-411, CHEBI:29954." [PMID:11484689, PMID:15024723, PMID:15712270, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000346
activin receptor type-1-like sequence variant P424T (human)
hACVRL1/var:P424T
"An activin receptor type-1-like (human) that has a Thr residue at the position equivalent to Pro-424 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Pro-424, CHEBI:30013." [PMID:9245985, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000347
activin receptor type-1-like sequence variant F425L (human)
hACVRL1/var:F425L
"An activin receptor type-1-like (human) that has a Leu residue at the position equivalent to Phe-425 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Phe-425, CHEBI:30006." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000348
activin receptor type-1-like sequence variant F425V (human)
hACVRL1/var:F425V
"An activin receptor type-1-like (human) that has a Val residue at the position equivalent to Phe-425 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Phe-425, CHEBI:30015." [PMID:15712270, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000349
activin receptor type-1-like sequence variant F425del (human)
hACVRL1/var:F425del
"An activin receptor type-1-like (human) that has a single-residue deletion at the position equivalent to Phe-425 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, 22-423, 425-503." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000350
activin receptor type-1-like sequence variant R67Q (human)
hACVRL1/var:R67Q
"An activin receptor type-1-like (human) that has a Gln residue at the position equivalent to Arg-67 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-67, CHEBI:30011." [PMID:14684682, PMID:9245985, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000351
activin receptor type-1-like sequence variant R479L (human)
hACVRL1/var:R479L
"An activin receptor type-1-like (human) that has a Leu residue at the position equivalent to Arg-479 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-479, CHEBI:30006." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000352
activin receptor type-1-like sequence variant A482V (human)
hACVRL1/var:A482V
"An activin receptor type-1-like (human) that has a Val residue at the position equivalent to Ala-482 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Ala-482, CHEBI:30015." [PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000353
activin receptor type-1-like sequence variant R484W (human)
hACVRL1/var:R484W
"An activin receptor type-1-like (human) that has a Trp residue at the position equivalent to Arg-484 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-484, CHEBI:29954." [PMID:11484689, PMID:15024723, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000354
activin receptor type-1-like sequence variant K487T (human)
hACVRL1/var:K487T
"An activin receptor type-1-like (human) that has a Thr residue at the position equivalent to Lys-487 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Lys-487, CHEBI:30013." [PMID:14684682, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000355
activin receptor type-1-like sequence variant GA48/49EP (human)
hACVRL1/var:(GA48/49EP)
"An activin receptor type-1-like (human) that has Glu and Pro residues at positions equivalent to Gly-48 and Ala-49 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Gly-48, CHEBI:29972|Ala-49, CHEBI:46217." [PMID:10767348, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000356
activin receptor type-1-like sequence variant R67W (human)
hACVRL1/var:R67W
"An activin receptor type-1-like (human) that has a Trp residue at the position equivalent to Arg-67 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Arg-67, CHEBI:29954." [PMID:15712270, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000357
activin receptor type-1-like sequence variant C77W (human)
hACVRL1/var:C77W
"An activin receptor type-1-like (human) that has a Trp residue at the position equivalent to Cys-77 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Cys-77, CHEBI:29954." [PMID:10694922, PMID:14684682, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000358
activin receptor type-1-like sequence variant N96D (human)
hACVRL1/var:N96D
"An activin receptor type-1-like (human) that has an Asp residue at the position equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Asn-96, CHEBI:29958." [PMID:10694922, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000359
activin receptor type-1-like sequence variant D179A (human)
hACVRL1/var:D179A
"An activin receptor type-1-like (human) that has an Ala residue at the position equivalent to Asp-179 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Asp-179, CHEBI:46217." [PMID:14684682, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000360
activin receptor type-1-like sequence variant G211D (human)
hACVRL1/var:G211D
"An activin receptor type-1-like (human) that has an Asp residue at the position equivalent to Gly-211 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Gly-211, CHEBI:29958." [PMID:14684682, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:P37023-1
activin receptor type-1-like isoform 1 (human)
hACVRL1/iso:1
"An activin receptor type-1-like isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000064347
activin receptor type-1-like, signal peptide removed form (human)
hACVRL1/SigPep-
"An activin receptor type-1-like (human) that has had the signal peptide removed. UniProtKB:P37023, 22-503." [PRO:DNx, Reactome:R-HSA-8858382]

organism-modification


PR:000067378
activin receptor type-1-like deaminated 1 (human)
hACVRL1/Deam:1
"An activin receptor type-1-like (human) that has been deaminated on the residue at the position equivalent to Asn-475 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Asn-475, MOD:00684." [IEDB_epitope:1365326, PRO:DNx]

organism-gene


PR:P80203
activin receptor type-1-like (rat)
rACVRL1
"An activin receptor type-1-like that is encoded in the genome of rat." [OMA:P80203, PRO:DNx]

organism-gene


PR:Q61288
activin receptor type-1-like (mouse)
mACVRL1
"An activin receptor type-1-like that is encoded in the genome of mouse." [OMA:Q61288, PRO:DNx]

organism-sequence


PR:Q61288-1
activin receptor type-1-like isoform 1 (mouse)
mACVRL1/iso:1
"An activin receptor type-1-like isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
sequence


PR:000000316
activin receptor type-1-like isoform 1
ACVRL1/iso:1
"An activin receptor type-1-like that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37023-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P37023-1
activin receptor type-1-like isoform 1 (human)
hACVRL1/iso:1
"An activin receptor type-1-like isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-sequence


PR:Q61288-1
activin receptor type-1-like isoform 1 (mouse)
mACVRL1/iso:1
"An activin receptor type-1-like isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
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TGFBR2 forms found in complexes   

TGFBR2 Component
 Complexes
PR:000000523 TGFBR1/iso:1/SigPep-/Phos:1 PR:000025975 transforming growth factor beta type I receptor homodimeric complex phosphorylated form
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000006 TGFBR2
The type 1 receptors are characterized by the presence of a glycine-serine rich juxta-membrane domain (the GS-motif) that is critical for their activation		 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PIRSF:PIRSF037391
enablesGO:0005025 transforming growth factor beta receptor activity, type I PIRSF:PIRSF037391
GO:0019838 growth factor binding PANTHER:PTHR23255; PIRSF:PIRSF037391
PR:000000137 hBMPR1A/var:Y62D
UniProtKB:P36894, Tyr-62, CHEBI:29958		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000138 hBMPR1A/var:C82Y
UniProtKB:P36894, Cys-82, CHEBI:46858		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000139 hBMPR1A/var:C124R
UniProtKB:P36894, Cys-124, CHEBI:29952		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:11536076
PR:000000140 hBMPR1A/var:C130R
UniProtKB:P36894, Cys-130, CHEBI:29952		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12136244
PR:000000141 hBMPR1A/var:A338D
UniProtKB:P36894, Ala-338, CHEBI:29958		 associated_with_disease_progressionDO:6457 Cowden syndrome PMID:11536076
PR:000000142 hBMPR1A/var:C376Y
UniProtKB:P36894, Cys-376, CHEBI:46858		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:11536076
PR:000000143 hBMPR1A/var:R443C
UniProtKB:P36894, Arg-443, CHEBI:29950		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513; PMID:17344846
PR:000000144 hBMPR1A/var:M470T
UniProtKB:P36894, Met-470, CHEBI:30013		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12630959
PR:000000146 hBMPR1B/var:I200K
Example: UniProtKB:O00238-1, Ile-200, CHEBI:29967		 associated_with_disease_progressionDO:0050581 brachydactyly PMID:14523231
enablesNOT GO:0004674 protein serine/threonine kinase activity PMID:14523231
located_inGO:0009986 cell surface PMID:14523231
PR:000000147 hBMPR1B/var:R486W
Example: UniProtKB:O00238-1, Arg-486, CHEBI:29954		 associated_with_disease_progressionDO:0050581 brachydactyly PMID:14523231
enablesGO:0004674 protein serine/threonine kinase activity PMID:14523231
located_inGO:0009986 cell surface PMID:14523231
PR:000000186 hTGFBR1/var:T200I
UniProtKB:P36897, Thr-200, CHEBI:30009		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000187 hTGFBR1/var:10 located_inSO:0001605 amino_acid_insertion PMID:9661882
PR:000000188 hTGFBR1/var:11
UniProtKB:P36897, 1-23, 27-503		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9661882
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9661882
PR:000000189 hTGFBR1/var:K232E
Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16928994
PR:000000190 hTGFBR1/var:S241L
Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16596670; PMID:16791849
PR:000000191 hTGFBR1/var:N267H
Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16791849
PR:000000192 hTGFBR1/var:M318R
Example: UniProtKB:P36897-1, Met-318, CHEBI:29952		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000193 hTGFBR1/var:D400G
Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000194 hTGFBR1/var:R487P
Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342		 associated_with_disease_progressionDO:14756 vascular type Ehlers-Danlos syndrome PMID:15731757; PMID:16928994
PR:000000195 hTGFBR1/var:R487E
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:16791849; PMID:16928994
PR:000000196 hTGFBR1/var:R487W
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954		 associated_with_disease_progressionDO:14756 vascular type Ehlers-Danlos syndrome PMID:16928994
PR:000000200 hACVR1/var:R206H
UniProtKB:Q04771, Arg-206, CHEBI:29979		 associated_with_disease_progressionDO:13374 fibrodysplasia ossificans progressiva PMID:8397373
located_inGO:0005886 plasma membrane PMID:8397373
PR:000000317 hACVRL1/var:G48R
UniProtKB:P37023, Gly-48, CHEBI:29952		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000318 hACVRL1/var:E215K
UniProtKB:P37023, Glu-215, CHEBI:29967		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000319 hACVRL1/var:H222del
UniProtKB:P37023, 22-221, 223-503		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia UniProtKB_VAR:VAR_006209
located_inGO:0005886 plasma membrane PMID:14684682
PR:000000320 hACVRL1/var:S233del
UniProtKB:P37023, 22-232, 234-503		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia UniProtKB_VAR:VAR_026792
PR:000000321 hACVRL1/var:G223R
UniProtKB:P37023, Gly-223, CHEBI:29952		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000322 hACVRL1/var:K229R
UniProtKB:P37023, Lys-229, CHEBI:29952		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000323 hACVRL1/var:D254del
UniProtKB:P37023, 22-253, 255-503		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia UniProtKB_VAR:VAR_026793
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000324 hACVRL1/var:M376V
UniProtKB:P37023, Met-376, CHEBI:30015		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000325 hACVRL1/var:L285F
UniProtKB:P37023, Leu-285, CHEBI:29997		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000326 hACVRL1/var:A306P
UniProtKB:P37023, Ala-306, CHEBI:50342		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000327 hACVRL1/var:H314Y
UniProtKB:P37023, His-314, CHEBI:46858		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000328 hACVRL1/var:W50C
UniProtKB:P37023, Trp-50, CHEBI:29950		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:10767348; PMID:14684682; PMID:9245985
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000329 hACVRL1/var:S333I
UniProtKB:P37023, Ser-333, CHEBI:30009		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:10767348; PMID:14684682; PMID:9245985
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000330 hACVRL1/var:L337P
UniProtKB:P37023, Leu-337, CHEBI:50342		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000331 hACVRL1/var:C344Y
UniProtKB:P37023, Cys-344, CHEBI:46858		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:10767348; PMID:14684682
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000332 hACVRL1/var:A347P
UniProtKB:P37023, Ala-347, CHEBI:50342		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000333 hACVRL1/var:R374Q
UniProtKB:P37023, Arg-374, CHEBI:30011		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:14684682; PMID:15024723
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000334 hACVRL1/var:R374W
UniProtKB:P37023, Arg-374, CHEBI:29954		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:11170071; PMID:14684682; PMID:15712270; PMID:9245985
PR:000000335 hACVRL1/var:P378L
UniProtKB:P37023, Pro-378, CHEBI:30006		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:14684682
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000336 hACVRL1/var:E379K
UniProtKB:P37023, Glu-379, CHEBI:29967		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723; PMID:15712270
PR:000000337 hACVRL1/var:M376R
UniProtKB:P37023, Met-376, CHEBI:29952		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:8640225
PR:000000338 hACVRL1/var:D397G
UniProtKB:P37023, Asp-397, CHEBI:29947		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000339 hACVRL1/var:C51Y
UniProtKB:P37023, Cys-51, CHEBI:46858		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:11170071
PR:000000340 hACVRL1/var:I398N
UniProtKB:P37023, Ile-398, CHEBI:50347		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:11170071
PR:000000341 hACVRL1/var:W399S
UniProtKB:P37023, Trp-399, CHEBI:29999		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:11170071
PR:000000342 hACVRL1/var:E407D
UniProtKB:P37023, Glu-407, CHEBI:29958		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:10767348; PMID:15712270
PR:000000343 hACVRL1/var:R411P
UniProtKB:P37023, Arg-411, CHEBI:50342		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000344 hACVRL1/var:R411Q
UniProtKB:P37023, Arg-411, CHEBI:30011		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:14684682; PMID:15024723; PMID:8640225
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000345 hACVRL1/var:R411W
UniProtKB:P37023, Arg-411, CHEBI:29954		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:11484689; PMID:15024723; PMID:15712270
PR:000000346 hACVRL1/var:P424T
UniProtKB:P37023, Pro-424, CHEBI:30013		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:9245985
PR:000000347 hACVRL1/var:F425L
UniProtKB:P37023, Phe-425, CHEBI:30006		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000348 hACVRL1/var:F425V
UniProtKB:P37023, Phe-425, CHEBI:30015		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15712270
PR:000000349 hACVRL1/var:F425del
UniProtKB:P37023, 22-423, 425-503		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia UniProtKB_VAR:VAR_026812
PR:000000350 hACVRL1/var:R67Q
UniProtKB:P37023, Arg-67, CHEBI:30011		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:14684682; PMID:9245985
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000351 hACVRL1/var:R479L
UniProtKB:P37023, Arg-479, CHEBI:30006		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000352 hACVRL1/var:A482V
UniProtKB:P37023, Ala-482, CHEBI:30015		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15024723
PR:000000353 hACVRL1/var:R484W
UniProtKB:P37023, Arg-484, CHEBI:29954		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:11484689; PMID:15024723
PR:000000354 hACVRL1/var:K487T
UniProtKB:P37023, Lys-487, CHEBI:30013		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:14684682
located_inGO:0005886 plasma membrane PMID:14684682
PR:000000355 hACVRL1/var:(GA48/49EP)
UniProtKB:P37023, Gly-48, CHEBI:29972|Ala-49, CHEBI:46217		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia UniProtKB_VAR:VAR_026784
PR:000000356 hACVRL1/var:R67W
UniProtKB:P37023, Arg-67, CHEBI:29954		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:15712270
PR:000000357 hACVRL1/var:C77W
UniProtKB:P37023, Cys-77, CHEBI:29954		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:10694922; PMID:14684682
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000000358 hACVRL1/var:N96D
UniProtKB:P37023, Asn-96, CHEBI:29958		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:10694922
PR:000000359 hACVRL1/var:D179A
UniProtKB:P37023, Asp-179, CHEBI:46217		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:14684682
located_inGO:0009986 cell surface PMID:14684682
PR:000000360 hACVRL1/var:G211D
UniProtKB:P37023, Gly-211, CHEBI:29958		 associated_with_disease_progressionDO:1270 hereditary hemorrhagic telangiectasia PMID:14684682
enablesNOT GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:14684682
located_inGO:0005783 endoplasmic reticulum PMID:14684682
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:7774578
GO:0007165 signal transduction PMID:8242743
GO:0007181 transforming growth factor beta receptor complex assembly PMID:8947046
enablesGO:0005025 transforming growth factor beta receptor activity, type I PMID:7774578; PMID:8947046
located_inGO:0005886 plasma membrane PMID:8947046
PR:000036422 hBMPR1A/iso:1/Phos:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:12065756
GO:0030509 BMP signaling pathway PMID:12829744
enablesGO:0004674 protein serine/threonine kinase activity PMID:12829744
located_inGO:0009986 cell surface PMID:10712517
GO:0043235 receptor complex PMID:12829744; PMID:15940369
PR:000036423 mBMPR1A/iso:1/Phos:1 enablesGO:0046332 SMAD binding PMID:10814522; PMID:9738003
PR:000036425 mBMPR1B/iso:1/Phos:1 acts_upstream_of_or_withinGO:0001501 skeletal system development PMID:14523231
GO:0001502 cartilage condensation PMID:10631181; PMID:14523231
GO:0035108 limb morphogenesis PMID:14523231
located_inGO:0009986 cell surface PMID:10712517; PMID:14523231
GO:0043235 receptor complex PMID:10712517
PR:000036426 hBMPR1B/iso:1/Phos:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:10051328
GO:0045597 positive regulation of cell differentiation PMID:14523231
PR:000036432 hTGFBR1/iso:1/SigPep-
UniProtKB:P36897-1, 34-503		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8242743
GO:0007181 transforming growth factor beta receptor complex assembly PMID:8242743
located_inGO:0005886 plasma membrane PMID:8242743
PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:12065756
PR:000036435 hACVR1/iso:1/SigPep-/Phos:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8242742; PMID:8389764
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8389764
GO:0048185 activin binding PMID:8242742
located_inGO:0005886 plasma membrane PMID:8242742; PMID:8397373
GO:0048179 activin receptor complex PMID:8242742
PR:000036436 mACVR1/iso:1/SigPep-/Phos:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:11376112
PR:000036437 hACVR1B/iso:1/Phos:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:12065756
enablesGO:0016361 activin receptor activity, type I PMID:8622651
GO:0046332 SMAD binding PMID:12065756
located_inGO:0005886 plasma membrane PMID:8397373
GO:0009986 cell surface PMID:12665502
PR:000036439 hACVR1C/iso:1/Phos:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:12065756
GO:0042981 regulation of apoptotic process PMID:15531507
enablesGO:0016361 activin receptor activity, type I PMID:12063393; PMID:15196700
located_inGO:0005886 plasma membrane PMID:12606401
GO:0048179 activin receptor complex PMID:15531507
PR:O00238-1 hBMPR1B/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:10051328
PR:P36894-1 hBMPR1A/iso:1 located_inGO:0016020 membrane PMID:8397373
GO:0043235 receptor complex PMID:15940369
PR:P36895-1 mBMPR1A/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:10814522
PR:P36896-1 hACVR1B/iso:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:11069203
PR:P36896-2 hACVR1B/iso:2 enablesNOT GO:0016361 activin receptor activity, type I PMID:11117535; PMID:8636304
located_inGO:0005886 plasma membrane PMID:11117535; PMID:8636304
PR:P36896-3 hACVR1B/iso:3 enablesNOT GO:0016361 activin receptor activity, type I PMID:11117535; PMID:8636304
located_inGO:0005886 plasma membrane PMID:11117535; PMID:8636304
PR:P36897-1 hTGFBR1/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8242743
PR:P36898-1 mBMPR1B/iso:1 acts_upstream_of_or_withinGO:0001501 skeletal system development PMID:14523231
GO:0001502 cartilage condensation PMID:14523231
GO:0035108 limb morphogenesis PMID:14523231
located_inGO:0009986 cell surface PMID:10712517
PR:P37023-1 hACVRL1/iso:1 acts_upstream_of_or_withinGO:0001525 angiogenesis PMID:12453878
GO:0006468 protein phosphorylation PMID:9920917
GO:0008015 blood circulation PMID:9245985
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8242742; PMID:9245985
GO:0005025 transforming growth factor beta receptor activity, type I PMID:8242742
GO:0016361 activin receptor activity, type I PMID:8242742
GO:0046332 SMAD binding PMID:9920917
GO:0048185 activin binding PMID:8242742
GO:0050431 transforming growth factor beta binding PMID:8242742
located_inGO:0005886 plasma membrane PMID:8242742; PMID:8397373
GO:0009986 cell surface PMID:8242742
PR:Q61288-1 mACVRL1/iso:1 acts_upstream_of_or_withinGO:0001525 angiogenesis PMID:10716993
GO:0006468 protein phosphorylation PMID:14580334
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:14580334
enablesGO:0046332 SMAD binding PMID:14580334
PR:Q8NER5-4 hACVR1C/iso:4 located_inGO:0005886 plasma membrane PMID:12606401