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Protein Ontology report - TGF-beta receptor type-2
PR:000000005 - http://purl.obolibrary.org/obo/PR_000000005
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000005   
  PRO nameTGF-beta receptor type-2 
  Synonyms
PRO-Short-label: EXACT:TGFBR2
Other: EXACT:TbetaR-II | TGF-beta receptor type II | TGF-beta type II receptor | TGFR-2 | transforming growth factor-beta receptor type II
  Definition"A protein that is a translation product of the human TGFBR2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  CommentThe core domain organization is composed of a signal peptide followed by a Transforming growth factor beta receptor 2 ectodomain (Pfam:PF08917), a transmembrane domain and a C-terminal Protein kinase domain (Pfam:PF00069). 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 21                                        
         Modification7                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037393;IUPHARobj:1795
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000005 TGF-beta receptor type-2
TGFBR2
Yes
organism-gene


PR:P37173 TGF-beta receptor type-2 (human)
hTGFBR2

organism-sequence


PR:000000050 TGF-beta receptor type-2 sequence variant L308P (human)
hTGFBR2/var:L308P
Yes
organism-sequence


PR:000000051 TGF-beta receptor type-2 sequence variant R460H (human)
hTGFBR2/var:R460H
Yes
organism-sequence


PR:000000052 TGF-beta receptor type-2 sequence variant R460C (human)
hTGFBR2/var:R460C
Yes
organism-sequence


PR:000000053 TGF-beta receptor type-2 sequence variant E526Q (human)
hTGFBR2/var:E526Q
Yes
organism-sequence


PR:000000054 TGF-beta receptor type-2 sequence variant R528C (human)
hTGFBR2/var:R528C
Yes
organism-sequence


PR:000000055 TGF-beta receptor type-2 sequence variant R528H (human)
hTGFBR2/var:R528H
Yes
organism-sequence


PR:000000056 TGF-beta receptor type-2 sequence variant R537C (human)
hTGFBR2/var:R537C
Yes
organism-sequence


PR:000000057 TGF-beta receptor type-2 sequence variant G357W (human)
hTGFBR2/var:G357W
Yes
organism-sequence


PR:000000058 TGF-beta receptor type-2 sequence variant T315M (human)
hTGFBR2/var:T315M
Yes
organism-sequence


PR:000000059 TGF-beta receptor type-2 sequence variant Y336N (human)
hTGFBR2/var:Y336N
Yes
organism-sequence


PR:000000060 TGF-beta receptor type-2 sequence variant A355P (human)
hTGFBR2/var:A355P
Yes
organism-sequence


PR:000000061 TGF-beta receptor type-2 sequence variant V387M (human)
hTGFBR2/var:V387M
Yes
organism-sequence


PR:000000062 TGF-beta receptor type-2 sequence variant N435S (human)
hTGFBR2/var:N435S
Yes
organism-sequence


PR:000000063 TGF-beta receptor type-2 sequence variant V447A (human)
hTGFBR2/var:V447A
Yes
organism-sequence


PR:000000064 TGF-beta receptor type-2 sequence variant S449F (human)
hTGFBR2/var:S449F
Yes
organism-sequence


PR:000000065 TGF-beta receptor type-2 sequence variant L452M (human)
hTGFBR2/var:L452M
Yes
organism-sequence


PR:P37173-1 TGF-beta receptor type-2 isoform RII-1 (human)
hTGFBR2/iso:RII-1

organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-sequence


PR:P37173-2 TGF-beta receptor type-2 isoform RII-2 (human)
hTGFBR2/iso:RII-2
Yes
organism-sequence


PR:P37173-3 TGF-beta receptor type-2 isoform h3 (human)
hTGFBR2/iso:h3

organism-modification


PR:000085798 TGF-beta receptor type-2, signal peptide removed form (human)
hTGFBR2/SigPep-

organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000049434 TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)
hTGFBR2/SigPep-/Nedd:1

organism-modification


PR:000060724 TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human)
hTGFBR2/var:Y470D/SigPep-

organism-modification


PR:000062611 TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human)
hTGFBR2/var:E526Q/SigPep-

organism-modification


PR:000062709 TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human)
hTGFBR2/var:R528C/SigPep-

organism-modification


PR:000062958 TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human)
hTGFBR2/var:D522N/SigPep-

organism-modification


PR:000064130 TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human)
hTGFBR2/var:R528H/SigPep-

organism-gene


PR:P38438 TGF-beta receptor type-2 (rat)
rTGFBR2

organism-gene


PR:Q62312 TGF-beta receptor type-2 (mouse)
mTGFBR2

organism-sequence


PR:Q62312-1 TGF-beta receptor type-2 isoform RII-2 (mouse)
mTGFBR2/iso:RII-2
Yes
organism-sequence


PR:Q62312-2 TGF-beta receptor type-2 isoform RII-1 (mouse)
mTGFBR2/iso:RII-1
Yes
organism-gene


PR:Q90999 TGF-beta receptor type-2 (chicken)
chick-TGFBR2

sequence


PR:000000048 TGF-beta receptor type-2 isoform RII-1
TGFBR2/iso:RII-1

organism-sequence


PR:P37173-1 TGF-beta receptor type-2 isoform RII-1 (human)
hTGFBR2/iso:RII-1

organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-sequence


PR:Q62312-2 TGF-beta receptor type-2 isoform RII-1 (mouse)
mTGFBR2/iso:RII-1
Yes
modification


PR:000000198 TGF-beta receptor type-2 isoform RII-1 phosphorylated form
TGFBR2/iso:RII-1/PhosRes+

modification


PR:000000410 TGF-beta receptor type-2 isoform RII-1 phosphorylated 1
TGFBR2/iso:RII-1/Phos:1

modification


PR:000003175 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated form
TGFBR2/iso:RII-1/SigPep-/PhosRes+

modification


PR:000003176 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1
TGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
modification


PR:000000409 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form
TGFBR2/iso:RII-1/SigPep-

modification


PR:000003175 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated form
TGFBR2/iso:RII-1/SigPep-/PhosRes+

modification


PR:000003176 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1
TGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
sequence


PR:000000049 TGF-beta receptor type-2 isoform RII-2
TGFBR2/iso:RII-2

organism-sequence


PR:P37173-2 TGF-beta receptor type-2 isoform RII-2 (human)
hTGFBR2/iso:RII-2
Yes
organism-sequence


PR:Q62312-1 TGF-beta receptor type-2 isoform RII-2 (mouse)
mTGFBR2/iso:RII-2
Yes
modification


PR:000018266 TGF-beta receptor type-2, signal peptide removed form
TGFBR2/SigPep-

modification


PR:000000409 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form
TGFBR2/iso:RII-1/SigPep-

modification


PR:000003175 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated form
TGFBR2/iso:RII-1/SigPep-/PhosRes+

modification


PR:000003176 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1
TGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000085798 TGF-beta receptor type-2, signal peptide removed form (human)
hTGFBR2/SigPep-

organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000049434 TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)
hTGFBR2/SigPep-/Nedd:1

organism-modification


PR:000060724 TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human)
hTGFBR2/var:Y470D/SigPep-

organism-modification


PR:000062611 TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human)
hTGFBR2/var:E526Q/SigPep-

organism-modification


PR:000062709 TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human)
hTGFBR2/var:R528C/SigPep-

organism-modification


PR:000062958 TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human)
hTGFBR2/var:D522N/SigPep-

organism-modification


PR:000064130 TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human)
hTGFBR2/var:R528H/SigPep-

modification


PR:000025412 TGF-beta receptor type-2 proteolytic cleavage product
TGFBR2/ClvPrd

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TGFBR2 forms found in complexes   

TGFBR2 Component
 Complexes
PR:000003176 TGFBR2/iso:RII-1/SigPep-/Phos:1 PR:000025976 transforming growth factor beta type II receptor homodimeric complex phosphorylated form
PR:000025962 hTGFBR2/iso:RII-1/SigPep-/Phos:1 PR:000025963 transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000005 TGFBR2 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PIRSF:PIRSF037393
GO:0007179 transforming growth factor beta receptor signaling pathway PIRSF:PIRSF037393
GO:0042127 regulation of cell population proliferation PIRSF:PIRSF037393
enablesGO:0004672 protein kinase activity PIRSF:PIRSF037393
GO:0005515 protein binding PIRSF:PIRSF037393
PR:000000050 hTGFBR2/var:L308P
Example: UniProtKB:P37173-1, Leu-308, CHEBI:50342		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15235604
enablesNOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604
PR:000000051 hTGFBR2/var:R460H
Example: UniProtKB:P37173-1, Arg-460, CHEBI:29979		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000052 hTGFBR2/var:R460C
Example: UniProtKB:P37173-1, Arg-460, CHEBI:29950		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000053 hTGFBR2/var:E526Q
Example: UniProtKB:P37173-1, Glu-526, CHEBI:30011		 associated_with_disease_progressionDO:3748 esophagus squamous cell carcinoma PMID:10789724
enablesNOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:10789724
PR:000000054 hTGFBR2/var:R528C
Example: UniProtKB:P37173-1, Arg-528, CHEBI:29950		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000055 hTGFBR2/var:R528H
Example: UniProtKB:P37173-1, Arg-528, CHEBI:29979		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000056 hTGFBR2/var:R537C
Example: UniProtKB:P37173-1, Arg-537, CHEBI:29950		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15235604
enablesNOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604
PR:000000057 hTGFBR2/var:G357W
Example: UniProtKB:P37173-1, Gly-357, CHEBI:29954		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000058 hTGFBR2/var:T315M
Example: UniProtKB:P37173-1, Thr-315, CHEBI:16044		 acts_upstream_of_or_withinGO:0008284 positive regulation of cell population proliferation PMID:9590282
associated_with_disease_progressionDO:3883 Lynch syndrome PMID:9590282
PR:000000059 hTGFBR2/var:Y336N
Example: UniProtKB:P37173-1, Tyr-336, CHEBI:50347		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000060 hTGFBR2/var:A355P
Example: UniProtKB:P37173-1, Ala-355, CHEBI:50342		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:15731757
associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15731757
located_inGO:0016020 membrane PMID:15731757
PR:000000061 hTGFBR2/var:V387M
Example: UniProtKB:P37173-1, Val-387, CHEBI:16044		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enablesdecreased GO:0005026 transforming growth factor beta receptor activity, type II relative to PR:000000409 TGF-beta receptor type-2 isoform 1 cleaved 1 PMID:11212236
located_inGO:0016020 membrane PMID:11212236
PR:000000062 hTGFBR2/var:N435S
Example: UniProtKB:P37173-1, Asn-435, CHEBI:29999		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enablesdecreased GO:0005026 transforming growth factor beta receptor activity, type II relative to PR:000000409 TGF-beta receptor type-2 isoform 1 cleaved 1 PMID:11212236
PR:000000063 hTGFBR2/var:V447A
Example: UniProtKB:P37173-1, Val-447, CHEBI:46217		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enablesdecreased GO:0005026 transforming growth factor beta receptor activity, type II relative to PR:000000409 TGF-beta receptor type-2 isoform 1 cleaved 1 PMID:11212236
located_inGO:0016020 membrane PMID:11212236
PR:000000064 hTGFBR2/var:S449F
Example: UniProtKB:P37173-1, Ser-449, CHEBI:29997		 associated_with_disease_progressionDO:0050466 Loeys-Dietz syndrome PMID:15235604
enablesNOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604
PR:000000065 hTGFBR2/var:L452M
Example: UniProtKB:P37173-1, Leu-452, CHEBI:16044		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enablesdecreased GO:0005026 transforming growth factor beta receptor activity, type II relative to PR:000000409 TGF-beta receptor type-2 isoform 1 cleaved 1 PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep-
UniProtKB:P37173-1, 23-567		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11483955
GO:0007181 transforming growth factor beta receptor complex assembly PMID:1310899; PMID:8774881
enablesGO:0005026 transforming growth factor beta receptor activity, type II PMID:11483955
GO:0005515 protein binding with PR:000000634 TGFB3/iso:1/Clv:1 PMID:1850637
GO:0005515 protein binding PMID:1850637
GO:0050431 transforming growth factor beta binding PMID:11850637; PMID:1310899
located_inGO:0016020 membrane PMID:1310899
PR:P37173-2 hTGFBR2/iso:RII-2 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:7959019; PMID:8635485
GO:0008284 positive regulation of cell population proliferation PMID:7959019
enablesGO:0005026 transforming growth factor beta receptor activity, type II PMID:7959019; PMID:8635485
GO:0050431 transforming growth factor beta binding PMID:8635485
PR:Q62312-1 mTGFBR2/iso:RII-2 enablesGO:0050431 transforming growth factor beta binding PMID:7957954
located_inGO:0016020 membrane PMID:7959019
PR:Q62312-2 mTGFBR2/iso:RII-1 located_inGO:0016020 membrane PMID:7957954