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Protein Ontology report - HLH DNA-binding protein inhibitor
PR:000000003 - http://purl.obolibrary.org/obo/PR_000000003
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000003   
  PRO nameHLH DNA-binding protein inhibitor 
  Synonyms
Other: EXACT:DNA-binding protein inhibitor ID
RELATED:ID protein
  Definition"A protein that belongs to the clade D of the bHLH proteins (see PMID:20219281) with a core domain composition consisting of a helix-loop-helix DNA-binding domain (Pfam:PF00010) (HLH), common to the basic HLH family of transcription factors, but lacking the DNA binding domain to the consensus E box response element (CANNTG). By binding to basic HLH transcription factors, proteins in this class regulate gene expression." [PMID:20219281, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 12                                        
         Sequence5                                                  Organism-Sequence 12                                        
         Modification7                                                  Organism-Modification 15                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF005808
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000003 HLH DNA-binding protein inhibitor
HLH DNA-binding protein inhibitor
Yes
gene


PR:000000039 DNA-binding protein inhibitor ID-1
ID1
Yes
organism-gene


PR:P20067 DNA-binding protein inhibitor ID-1 (mouse)
mID1
Yes
organism-sequence


PR:P20067-1 DNA-binding protein inhibitor ID-1 isoform Long (mouse)
mID1/iso:Long

organism-sequence


PR:P20067-2 DNA-binding protein inhibitor ID-1 isoform Short (mouse)
mID1/iso:Short

organism-gene


PR:P41134 DNA-binding protein inhibitor ID-1 (human)
hID1
Yes
organism-sequence


PR:P41134-1 DNA-binding protein inhibitor ID-1 isoform ID-A (human)
hID1/iso:ID-A
Yes
organism-sequence


PR:P41134-2 DNA-binding protein inhibitor ID-1 isoform ID-B (human)
hID1/iso:ID-B

organism-modification


PR:000071543 DNA-binding protein inhibitor ID-1 cysteinylated 1 (human)
hID1/Cyst:1

organism-gene


PR:P41135 DNA-binding protein inhibitor ID-1 (rat)
rID1

organism-sequence


PR:P41135-1 DNA-binding protein inhibitor ID-1 isoform Long (rat)
rID1/iso:Long

organism-sequence


PR:P41135-2 DNA-binding protein inhibitor ID-1 isoform Short (rat)
rID1/iso:Short

sequence


PR:000000171 DNA-binding protein inhibitor ID-1 isoform 1
ID1/iso:1

organism-sequence


PR:P20067-2 DNA-binding protein inhibitor ID-1 isoform Short (mouse)
mID1/iso:Short

organism-sequence


PR:P41134-1 DNA-binding protein inhibitor ID-1 isoform ID-A (human)
hID1/iso:ID-A
Yes
sequence


PR:000000172 DNA-binding protein inhibitor ID-1 isoform 2
ID1/iso:2

organism-sequence


PR:P41134-2 DNA-binding protein inhibitor ID-1 isoform ID-B (human)
hID1/iso:ID-B

gene


PR:000000040 DNA-binding protein inhibitor ID-2
ID2
Yes
organism-gene


PR:P41136 DNA-binding protein inhibitor ID-2 (mouse)
mID2

organism-sequence


PR:P41136-1 DNA-binding protein inhibitor ID-2 isoform 1 (mouse)
mID2/iso:1
Yes
organism-modification


PR:000045376 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse)
mID2/iso:1/UnPhos:1

organism-gene


PR:P41137 DNA-binding protein inhibitor ID-2 (rat)
rID2

organism-modification


PR:000036428 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (rat)
rID2/iso:1/Phos:1
Yes
organism-modification


PR:000045377 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (rat)
rID2/iso:1/UnPhos:1
Yes
organism-gene


PR:Q02363 DNA-binding protein inhibitor ID-2 (human)
hID2

organism-sequence


PR:Q02363-1 DNA-binding protein inhibitor ID-2 isoform 1 (human)
hID2/iso:1

organism-modification


PR:000036427 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human)
hID2/iso:1/Phos:1
Yes
organism-modification


PR:000045368 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human)
hID2/iso:1/UnPhos:1
Yes
organism-modification


PR:000069807 DNA-binding protein inhibitor ID-2 sulfated 1 (human)
hID2/Sulf:1

organism-modification


PR:000079087 DNA-binding protein inhibitor ID-2 phosphorylated 1 (human)
hID2/Phos:1

sequence


PR:000000173 DNA-binding protein inhibitor ID-2 isoform 1
ID2/iso:1

organism-sequence


PR:P41136-1 DNA-binding protein inhibitor ID-2 isoform 1 (mouse)
mID2/iso:1
Yes
organism-modification


PR:000045376 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse)
mID2/iso:1/UnPhos:1

organism-sequence


PR:Q02363-1 DNA-binding protein inhibitor ID-2 isoform 1 (human)
hID2/iso:1

organism-modification


PR:000036427 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human)
hID2/iso:1/Phos:1
Yes
organism-modification


PR:000045368 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human)
hID2/iso:1/UnPhos:1
Yes
modification


PR:000000392 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated form
ID2/iso:1/PhosRes+

modification


PR:000000507 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1
ID2/iso:1/Phos:1

organism-modification


PR:000036427 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human)
hID2/iso:1/Phos:1
Yes
organism-modification


PR:000036428 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (rat)
rID2/iso:1/Phos:1
Yes
modification


PR:000045375 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1
ID2/iso:1/PhosRes-

organism-modification


PR:000045368 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human)
hID2/iso:1/UnPhos:1
Yes
organism-modification


PR:000045376 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse)
mID2/iso:1/UnPhos:1

organism-modification


PR:000045377 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (rat)
rID2/iso:1/UnPhos:1
Yes
gene


PR:000000041 DNA-binding protein inhibitor ID-3
ID3
Yes
organism-gene


PR:P41133 DNA-binding protein inhibitor ID-3 (mouse)
mID3

organism-sequence


PR:P41133-1 DNA-binding protein inhibitor ID-3 isoform 1 (mouse)
mID3/iso:1
Yes
organism-modification


PR:000036430 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse)
mID3/iso:1/Ubiq:1
Yes
organism-gene


PR:P41138 DNA-binding protein inhibitor ID-3 (rat)
rID3

organism-gene


PR:Q02535 DNA-binding protein inhibitor ID-3 (human)
hID3
Yes
organism-sequence


PR:Q02535-1 DNA-binding protein inhibitor ID-3 isoform 1 (human)
hID3/iso:1
Yes
organism-modification


PR:000036429 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human)
hID3/iso:1/Phos:1
Yes
organism-modification


PR:000064894 DNA-binding protein inhibitor ID-3 methylated 1 (human)
hID3/Me:1

organism-modification


PR:000068204 DNA-binding protein inhibitor ID-3 cysteinylated 1 (human)
hID3/Cyst:1

organism-modification


PR:000073735 DNA-binding protein inhibitor ID-3 methylated 2 (human)
hID3/Me:2

organism-modification


PR:000081463 DNA-binding protein inhibitor ID-3 cysteinylated 2 (human)
hID3/Cyst:2

organism-modification


PR:000082453 DNA-binding protein inhibitor ID-3 phosphorylated 1 (human)
hID3/Phos:1

sequence


PR:000000174 DNA-binding protein inhibitor ID-3 isoform 1
ID3/iso:1

organism-sequence


PR:P41133-1 DNA-binding protein inhibitor ID-3 isoform 1 (mouse)
mID3/iso:1
Yes
organism-modification


PR:000036430 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse)
mID3/iso:1/Ubiq:1
Yes
organism-sequence


PR:Q02535-1 DNA-binding protein inhibitor ID-3 isoform 1 (human)
hID3/iso:1
Yes
organism-modification


PR:000036429 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human)
hID3/iso:1/Phos:1
Yes
modification


PR:000000393 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated form
ID3/iso:1/PhosRes+

modification


PR:000000508 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1
ID3/iso:1/Phos:1

organism-modification


PR:000036429 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human)
hID3/iso:1/Phos:1
Yes
modification


PR:000000394 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated form
ID3/iso:1/UbiqLys+

modification


PR:000000509 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1
ID3/iso:1/Ubiq:1

organism-modification


PR:000036430 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse)
mID3/iso:1/Ubiq:1
Yes
gene


PR:000000042 DNA-binding protein inhibitor ID-4
ID4
Yes
organism-gene


PR:P41139 DNA-binding protein inhibitor ID-4 (mouse)
mID4

organism-sequence


PR:P41139-1 DNA-binding protein inhibitor ID-4 isoform 1 (mouse)
mID4/iso:1
Yes
organism-gene


PR:P47928 DNA-binding protein inhibitor ID-4 (human)
hID4

organism-sequence


PR:P47928-1 DNA-binding protein inhibitor ID-4 isoform 1 (human)
hID4/iso:1
Yes
organism-gene


PR:Q90X12 helix-loop-helix protein (chicken)
chick-ID4

sequence


PR:000000175 DNA-binding protein inhibitor ID-4 isoform 1
ID4/iso:1

organism-sequence


PR:P41139-1 DNA-binding protein inhibitor ID-4 isoform 1 (mouse)
mID4/iso:1
Yes
organism-sequence


PR:P47928-1 DNA-binding protein inhibitor ID-4 isoform 1 (human)
hID4/iso:1
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIPR:P20067 mID1 PMID:12498716
PR:P41133-1 mID3/iso:1 PMID:2000388
GO:0006355 regulation of DNA-templated transcriptionPR:000000003 HLH DNA-binding protein inhibitor PIRSF:PIRSF005808
GO:0007275 multicellular organism developmentPR:Q02535-1 hID3/iso:1 PMID:1628620
GO:0008284 positive regulation of cell population proliferationPR:P41139-1 mID4/iso:1 PMID:15882580
GO:0030509 BMP signaling pathwayPR:P20067 mID1 PMID:15820682
PR:P41139-1 mID4/iso:1 PMID:15280210
GO:0045665 negative regulation of neuron differentiationPR:P41139-1 mID4/iso:1 PMID:15882580
GO:0045892 negative regulation of DNA-templated transcriptionPR:000000040 ID2 PIRSF:PIRSF500478
PR:000000041 ID3 PIRSF:PIRSF500479
PR:000000042 ID4 PIRSF:PIRSF500478
PR:000045368 hID2/iso:1/UnPhos:1 PMID:14627819; PMID:9029153
PR:P41134 hID1 PMID:15138269
PR:P41139-1 mID4/iso:1 PMID:8139914
PR:P47928-1 hID4/iso:1 PMID:11136250
PR:Q02535 hID3 PMID:14627819
PR:Q02535-1 hID3/iso:1 PMID:8437843
GO:0051726 regulation of cell cyclePR:000036427 hID2/iso:1/Phos:1 PMID:9029153
PR:000036429 hID3/iso:1/Phos:1 PMID:9372912
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionPR:P41134-1 hID1/iso:ID-A PMID:17855368

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0003700 DNA-binding transcription factor activityPR:000000003 HLH DNA-binding protein inhibitor PIRSF:PIRSF005808
GO:0003714 transcription corepressor activityPR:Q02535-1 hID3/iso:1 PMID:8437843
GO:0005515 protein bindingPR:P41134-1 hID1/iso:ID-A PMID:17855368
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
PR:P41139-1 mID4/iso:1 PMID:15280210
GO:0046983 protein dimerization activityPR:000000039 ID1 PANTHER:PTHR11723; PIRSF:PIRSF500477
PR:P41136-1 mID2/iso:1 PMID:10891368

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000036428 rID2/iso:1/Phos:1 PMID:11706002
PR:P41133-1 mID3/iso:1 PMID:15451666
PR:P41134 hID1 PMID:15138269
PR:P41136-1 mID2/iso:1 PMID:12878164
GO:0005737 cytoplasmPR:000036430 mID3/iso:1/Ubiq:1 PMID:15451666
PR:000045377 rID2/iso:1/UnPhos:1 PMID:11706002
PR:P41134-1 hID1/iso:ID-A PMID:17855368
PR:P41136-1 mID2/iso:1 PMID:12878164; PMID:15563451
PR:P41139-1 mID4/iso:1 PMID:15280210